The body burden and thyroid disruption in lizards (Eremias argus) living in benzoylurea pesticides-contaminated soil
文献类型：期刊论文
| 作者 | Hao, Weiyu; Xu, Peng; Wang, Yinghuan ; Guo, Baoyuan; Li, Jianzhong; Li, Jitong; Li, Wei; Wang, Huili; Chang, Jing
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| 刊名 | JOURNAL OF HAZARDOUS MATERIALS
 |
| 出版日期 | 2018-04-05 |
| 卷号 | 347页码:218-226 |
| 关键词 | Diflubenzuron Flufenoxuron Reptile Endocrine disruption Tissue distribution |
| ISSN号 | 0304-3894 |
| 文献子类 | Article |
| 英文摘要 | Dermal exposure is regarded as a potentially significant but understudied route for pesticides uptake in terrestrial reptiles. In this study, a native Chinese lizard was exposed to control, diflubenzuron or flufenoxuron contaminated soil (1.5 mg kg(-1)) for 35 days. Tissue distribution, liver lesions, thyroid hormone levels and transcription of most target genes were examined. The half-lives of diflubenzuron and flufenoxuron in the soil were 118.9 and 231.8 days, respectively. The accumulation of flufenoxuron in the liver, brain, kidney, heart, plasma and skin (1.4-35.4 mg kg(-1)) were higher than that of diflubenzuron (0-1.7 mg kg(-1)) at all time points. The skin permeability factor of flufenoxuron was more than 20-fold greater than that of diflubenzuron at the end of exposure. However, the liver was more vulnerable in the diflubenzuron exposure group. The alterations of triiodothyronine (T3) and thyroxine (T4) level after diflubenzuron or flufenoxuron exposure were accompanied with the changes in the transcription of target genes involved not only in hypothalamus-pituitary-thyroid (HPT) axis (suit, dio2, tr alpha and udp) but also in metabolism system (cypla and ahr). These results indicated that flufenoxuron produced greater body burdens to lizards through dermal exposure, whereas both diflubenzuron and flufenoxuron have the potential to disturb metabolism and thyroid endocrine system. (C) 2018 Elsevier B.V. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41299]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Hao, Weiyu,Xu, Peng,Wang, Yinghuan,et al. The body burden and thyroid disruption in lizards (Eremias argus) living in benzoylurea pesticides-contaminated soil[J]. JOURNAL OF HAZARDOUS MATERIALS,2018,347:218-226. |
| APA | Hao, Weiyu.,Xu, Peng.,Wang, Yinghuan.,Guo, Baoyuan.,Li, Jianzhong.,...&Chang, Jing.(2018).The body burden and thyroid disruption in lizards (Eremias argus) living in benzoylurea pesticides-contaminated soil.JOURNAL OF HAZARDOUS MATERIALS,347,218-226. |
| MLA | Hao, Weiyu,et al."The body burden and thyroid disruption in lizards (Eremias argus) living in benzoylurea pesticides-contaminated soil".JOURNAL OF HAZARDOUS MATERIALS 347(2018):218-226. |
入库方式： OAI收割
来源：生态环境研究中心
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