The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus)
文献类型：期刊论文
| 作者 | Xu, Peng; Wang, Yinghuan ; Han, Yongtao; Xie, Yun; Li, Wei
|
| 刊名 | CHEMOSPHERE
 |
| 出版日期 | 2018-11-01 |
| 卷号 | 211页码:591-599 |
| 关键词 | Eremias argus Dinotefuran Metabolism Distribution |
| ISSN号 | 0045-6535 |
| 文献子类 | Article |
| 英文摘要 | The Chinese lizards (Eremias argus) were used to evaluate the metabolism, distribution and effect of dinotefuran following oral exposed. The HPLC equipped with Q Exactive focus was used for metabolite identification and concentration analysis. After single oral administration, the time-concentration curves of dinotefuran and its metabolites were tissue-dependent. The liver and kidney were the major metabolic organs. Percutaneous and urinary excretions were the main ways for lizards to eliminate dinotefuran, and the urine output was the limiting factor. Nitro-reduction was an important process of the metabolism of dinotefuran that was dominated by aldehyde oxidase, and P450 enzymes were involved. The CYP3A4 and CYP2C19 played a crucial role in the other metabolic pathways of dinotefuran. The mRNA expressions of GST family were severely inhibited in liver, which showed dinotefuran might pose a risk of damaging the oxidative stress system in liver. Prolonged residuals of dinotefuran and its demethylation metabolite might enhance the risk of dinotefuran to brain. The results enrich and supplement the knowledge of the environmental fate of dinotefuran in reptiles. (C) 2018 Elsevier Ltd. All rights reserved. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41301]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Xu, Peng,Wang, Yinghuan,Han, Yongtao,et al. The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus)[J]. CHEMOSPHERE,2018,211:591-599. |
| APA | Xu, Peng,Wang, Yinghuan,Han, Yongtao,Xie, Yun,&Li, Wei.(2018).The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus).CHEMOSPHERE,211,591-599. |
| MLA | Xu, Peng,et al."The metabolism distribution and effect of dinotefuran in Chinese lizards (Eremias argus)".CHEMOSPHERE 211(2018):591-599. |
入库方式： OAI收割
来源：生态环境研究中心
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