The metabolism distribution and effect of imidacloprid in chinese lizards (Eremias argus) following oral exposure
文献类型：期刊论文
| 作者 | Li, Wei ; Wang, Yinghuan; Han, Yongtao; Xu, Peng; Guo, Baoyuan; Wang, Xiangyun
|
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2018-12-15 |
| 卷号 | 165页码:476-483 |
| 关键词 | Eremias argus Imidacloprid Metabolism Distribution |
| ISSN号 | 0147-6513 |
| 文献子类 | Article |
| 英文摘要 | Systematically evaluation of the metabolism, distribution and effect of imidacloprid in Chinese lizards (Eremias argus) were carried out following oral exposure. Imidacloprid-olefin-guanidine was prone to accumulate in the brain and caused potential neurotoxicity. Percutaneous and excretory excretions were the primary ways for the elimination of imidacloprid and its metabolites. Liver was the main site for hydroxy reduction and nitro-reduction metabolism of imidacloprid. The metabolism of imidacloprid was a complex process in which many metabolic enzymes participated. Aldehyde oxidase and CYP2C9 were the key enzymes in nitro-reduction process. CYP3A4 dominated the process of hydroxylation and denaturation. The increase in Glutathione S-transferase expression may be related to the removal of imidacloprid, but also related to the oxidative stress reaction that imidacloprid may cause in tissues, especially in the kidney. The findings enrich and supplement the knowledge of the environmental fate of imidacloprid in reptiles. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41302]  |
| 专题 | 生态环境研究中心_中国科学院环境生物技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Li, Wei,Wang, Yinghuan,Han, Yongtao,et al. The metabolism distribution and effect of imidacloprid in chinese lizards (Eremias argus) following oral exposure[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2018,165:476-483. |
| APA | Li, Wei,Wang, Yinghuan,Han, Yongtao,Xu, Peng,Guo, Baoyuan,&Wang, Xiangyun.(2018).The metabolism distribution and effect of imidacloprid in chinese lizards (Eremias argus) following oral exposure.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,165,476-483. |
| MLA | Li, Wei,et al."The metabolism distribution and effect of imidacloprid in chinese lizards (Eremias argus) following oral exposure".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 165(2018):476-483. |
入库方式： OAI收割
来源：生态环境研究中心
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。