Evaluating estrogenic and anti-estrogenic effect of endocrine disrupting chemicals (EDCs) by zebrafish (Danio rerio) embryo-based vitellogenin 1 (vtgl) mRNA expression
文献类型：期刊论文
| 作者 | Chen, Minjie; Liang, Yong; Song, Maoyong ; Sun, Yonghua; Wang, Ling; Wang, Chang; Pang, Shaochen; Zhang, Jie
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| 刊名 | COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY
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| 出版日期 | 2018 |
| 卷号 | 204页码:45-50 |
| ISSN号 | 1532-0456 |
| 关键词 | Zebrafish embryo Vitellogenin 1 Estrogenic effect Endocrine disrupting chemicals |
| 文献子类 | Article |
| 英文摘要 | By measuring the vitellogenin 1 (vtgl) expression through quantitative PCR and in situ hybridization, we used the zebrafish embryo as an in vivo model to access the estrogenic or anti-estrogenic effects of several endocrine disrupting chemicals (EDCs), such as natural estrogen 17 beta-estradiol (E2), estriol (E3), synthetic hormones including diethylstilbestrol (DES), 4-octyl phenol (OP), bisphenol A (BPA), tamoxifen (TMX) and 3-(2,3-dibromopropyl) isocyanurate (TBC). According to our data, the estrogenic effect Of the tested chemicals was ranked as: DES > E-2 > E-3 > OP > BPA, which is consistent with various in vivo and in vitro models. Therefore, the measurement of vtgl gene expression in zebrafish embryos would be a valuable method for screening EDCs including both environmental estrogens and anti-estrogens. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41089]  |
| 专题 | 生态环境研究中心_环境纳米材料实验室 |
| 推荐引用方式 GB/T 7714 | Chen, Minjie,Liang, Yong,Song, Maoyong,et al. Evaluating estrogenic and anti-estrogenic effect of endocrine disrupting chemicals (EDCs) by zebrafish (Danio rerio) embryo-based vitellogenin 1 (vtgl) mRNA expression[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,2018,204:45-50. |
| APA | Chen, Minjie.,Liang, Yong.,Song, Maoyong.,Sun, Yonghua.,Wang, Ling.,...&Zhang, Jie.(2018).Evaluating estrogenic and anti-estrogenic effect of endocrine disrupting chemicals (EDCs) by zebrafish (Danio rerio) embryo-based vitellogenin 1 (vtgl) mRNA expression.COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY,204,45-50. |
| MLA | Chen, Minjie,et al."Evaluating estrogenic and anti-estrogenic effect of endocrine disrupting chemicals (EDCs) by zebrafish (Danio rerio) embryo-based vitellogenin 1 (vtgl) mRNA expression".COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY 204(2018):45-50. |
入库方式： OAI收割
来源：生态环境研究中心
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