The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs)
文献类型:期刊论文
作者 | Wang, Zijian; Rao, Kaifeng; Ma, Mei; Wang, Donghong; Xu, Xiong; Huang, Chao |
刊名 | CHEMOSPHERE |
出版日期 | 2018-11-01 |
卷号 | 211页码:640-647 |
ISSN号 | 0045-6535 |
关键词 | Chlorinated PAHs (Cl-PAHs) Aryl hydrocarbon receptor (AhR) DNA-Damaging effect Genotoxicity |
文献子类 | Article |
英文摘要 | An increasing number of studies have indicated that environmental contamination with chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs) has been underestimated. However, insufficient available toxicological information on Cl-PAHs makes evaluating their risks to health challenging. Two in vitro bioassays were used in the present study to characterize the aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of 22 low-molecular-weight PAHs and their Cl-PAHs by using the EROD assay in rat hepatoma (H4IIE) cells and the SOS/umu test (S. typhimurium TA1535/pSK1002). Compared with their parent PAHs, most of the Cl-PAHs enhanced AhR-mediated activity in the EROD assay. 1,3,6,8-Tetrachloro-pyrene (1,3,6,8-Tetracl-Py) induced the greatest potency of EROD activity (83.1%-TCDD-max) and its single point ReP was 6.64 x 10(-6). Compared with their parent PAHs, several Cl-PAHs showed significant DNA-damaging effects in the SOS/umu test with the addition of S9, and the toxic equivalency of benzo[a]pyrene (TEQ(Bap)) was calculated for them. 9-Chloroanthracene (9-Ant) and 5,6-Dichloroacenaphthene (5,6-Did-Ace) had relatively high TEQ(Bap) (0.62 and 0.54, respectively). However, only 1,3,6,8-Tetracl-Py elicited strong DNA-damaging effects in the absence of S9. The degree of chlorination, the position of chlorine substitutions, and the structure of parent PAHs influenced the potency of low-molecular-weight PAHs with regard to their AhR activity and DNA-damaging effects. More concern should be raised for these environmentally relevant pollutants. (C) 2018 Published by Elsevier Ltd. |
源URL | [http://ir.rcees.ac.cn/handle/311016/41421] |
专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
推荐引用方式 GB/T 7714 | Wang, Zijian,Rao, Kaifeng,Ma, Mei,et al. The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs)[J]. CHEMOSPHERE,2018,211:640-647. |
APA | Wang, Zijian,Rao, Kaifeng,Ma, Mei,Wang, Donghong,Xu, Xiong,&Huang, Chao.(2018).The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs).CHEMOSPHERE,211,640-647. |
MLA | Wang, Zijian,et al."The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs)".CHEMOSPHERE 211(2018):640-647. |
入库方式: OAI收割
来源:生态环境研究中心
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