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Chinese Academy of Sciences Institutional Repositories Grid
The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs)

文献类型:期刊论文

作者Wang, Zijian; Rao, Kaifeng; Ma, Mei; Wang, Donghong; Xu, Xiong; Huang, Chao
刊名CHEMOSPHERE
出版日期2018-11-01
卷号211页码:640-647
ISSN号0045-6535
关键词Chlorinated PAHs (Cl-PAHs) Aryl hydrocarbon receptor (AhR) DNA-Damaging effect Genotoxicity
文献子类Article
英文摘要An increasing number of studies have indicated that environmental contamination with chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs) has been underestimated. However, insufficient available toxicological information on Cl-PAHs makes evaluating their risks to health challenging. Two in vitro bioassays were used in the present study to characterize the aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of 22 low-molecular-weight PAHs and their Cl-PAHs by using the EROD assay in rat hepatoma (H4IIE) cells and the SOS/umu test (S. typhimurium TA1535/pSK1002). Compared with their parent PAHs, most of the Cl-PAHs enhanced AhR-mediated activity in the EROD assay. 1,3,6,8-Tetrachloro-pyrene (1,3,6,8-Tetracl-Py) induced the greatest potency of EROD activity (83.1%-TCDD-max) and its single point ReP was 6.64 x 10(-6). Compared with their parent PAHs, several Cl-PAHs showed significant DNA-damaging effects in the SOS/umu test with the addition of S9, and the toxic equivalency of benzo[a]pyrene (TEQ(Bap)) was calculated for them. 9-Chloroanthracene (9-Ant) and 5,6-Dichloroacenaphthene (5,6-Did-Ace) had relatively high TEQ(Bap) (0.62 and 0.54, respectively). However, only 1,3,6,8-Tetracl-Py elicited strong DNA-damaging effects in the absence of S9. The degree of chlorination, the position of chlorine substitutions, and the structure of parent PAHs influenced the potency of low-molecular-weight PAHs with regard to their AhR activity and DNA-damaging effects. More concern should be raised for these environmentally relevant pollutants. (C) 2018 Published by Elsevier Ltd.
源URL[http://ir.rcees.ac.cn/handle/311016/41421]  
专题生态环境研究中心_中国科学院饮用水科学与技术重点实验室
推荐引用方式
GB/T 7714
Wang, Zijian,Rao, Kaifeng,Ma, Mei,et al. The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs)[J]. CHEMOSPHERE,2018,211:640-647.
APA Wang, Zijian,Rao, Kaifeng,Ma, Mei,Wang, Donghong,Xu, Xiong,&Huang, Chao.(2018).The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs).CHEMOSPHERE,211,640-647.
MLA Wang, Zijian,et al."The aryl hydrocarbon receptor (AhR) activity and DNA-damaging effects of chlorinated polycyclic aromatic hydrocarbons (Cl-PAHs)".CHEMOSPHERE 211(2018):640-647.

入库方式: OAI收割

来源:生态环境研究中心

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