Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus)
文献类型：期刊论文
| 作者 | Zha, Jinmiao; Yuan, Lilai; Hou, Rui ; Chen, Rui; Hong, Xiangsheng
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| 刊名 | ENVIRONMENTAL SCIENCE & TECHNOLOGY
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| 出版日期 | 2018-10-16 |
| 卷号 | 52期号:20页码:11895-11903 |
| ISSN号 | 0013-936X |
| 文献子类 | Article |
| 英文摘要 | The neurotoxicity of triphenyl phosphate (TPHP) in exposed humans and laboratory animals is under debate. The rapid crossing of the blood-brain barrier (BBB) and high distribution of TPHP in fish brains have raised widespread concerns about potential neurotoxicity. Adult male Chinese rare minnows (Gobiocypris rarus) were used as a model and exposed to 0, 20, or 100 mu g/L TPHP for 28 days. We evaluated the BBB permeability, neuroinflammatory response, cell proliferation and apoptosis, synaptic plasticity and synapse loss in fish brains via the learning/memory performance of fish following 28 days of TPHP exposure. TPHP significantly increased the BBB permeability, activated the neuroinflammatory response, and decreased the tight junction-related mRNA levels of claudin-5 alpha and occludin in the fish brain. In addition, cell proliferation was inhibited by treatment with 100 mu g/L TPHP, but no significant apoptosis was observed in the brain. Fish exposed to 100 mu g/L TPHP exhibited significantly decreased dendritic arborization in pyramidal neurons in the cerebellum (Ce), and the maze test indicated impaired learning/memory performance. Taken together, these findings provide scientific evidence that TPHP is neurotoxic to fish and further suggest that TPHP may not be a safe alternative for aquatic organisms. |
| 源URL | [http://ir.rcees.ac.cn/handle/311016/41431]  |
| 专题 | 生态环境研究中心_中国科学院饮用水科学与技术重点实验室 |
| 推荐引用方式 GB/T 7714 | Zha, Jinmiao,Yuan, Lilai,Hou, Rui,et al. Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus)[J]. ENVIRONMENTAL SCIENCE & TECHNOLOGY,2018,52(20):11895-11903. |
| APA | Zha, Jinmiao,Yuan, Lilai,Hou, Rui,Chen, Rui,&Hong, Xiangsheng.(2018).Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus).ENVIRONMENTAL SCIENCE & TECHNOLOGY,52(20),11895-11903. |
| MLA | Zha, Jinmiao,et al."Triphenyl Phosphate (TPHP)-Induced Neurotoxicity in Adult Male Chinese Rare Minnows (Gobiocypris rarus)".ENVIRONMENTAL SCIENCE & TECHNOLOGY 52.20(2018):11895-11903. |
入库方式： OAI收割
来源：生态环境研究中心
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