Using a simplified framework, we attempt to explain the recent DAMPE cosmic e(+) + e(-) flux excess by leptophilic Dirac fermion dark matter (LDM). The scalar (Phi(0)) and vector (Phi(1)) mediator fields connecting LDM and Standard Model particles are discussed. We find that the couplings P circle times S, P circle times P, V circle times A and V circle times V can produce the right bump in e(+) + e(-) flux for a DM mass around 1.5 TeV with a natural thermal annihilation cross-section < sigma v > similar to 3 x 10(-26)cm(3)/s today. Among them, V circle times V coupling is tightly constrained by PandaX-II data (although LDM-nucleus scattering appears at one-loop level) and the surviving samples appear in the resonant region, m(Phi 1) similar or equal to 2m(chi). We also study the related collider signatures, such as dilepton production pp -> Phi(1) -> l(+) l(-), and muon g - 2 anomaly. Finally, we present a possible U(1)(X) realization for such leptophilic dark matter.