We report a nominally high-confidence gamma-ray quasi-periodic modulation in the blazar PKS 0301-243. For this target, we analyze its Fermi-LAT Pass 8 data from 2008 August to 2017 May. Two techniques, i.e., maximum likelihood optimization and exposure-weighted aperture photometry, are used to build the gamma-ray light curves. Then, both the Lomb-Scargle periodogram and the weighted wavelet Z-transform are applied to the light curves to search for period signals. A quasi-periodicity with a period of 2.1 +/- 0.3 yr appears at the significance level of similar to 5 sigma, although it should be noted that this putative quasi-period variability is seen in a data set that is barely four times longer. We speculate that this gamma-ray quasi-periodic modulation may be evidence of a binary supermassive black hole.