Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide
文献类型：期刊论文
| 作者 | Wang, Wei1; Xin, Jingxue2,3; Yang, Xiao1,2; Lam, Sin Man1; Shui, Guanghou1; Wang, Yong3,4 ; Huang, Xun1,2
|
| 刊名 | BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
 |
| 出版日期 | 2019-02-01 |
| 卷号 | 1864期号:2页码:168-180 |
| 关键词 | Lipid homeostasis TAG PI HexCer Metabolic reprogramming |
| ISSN号 | 1388-1981 |
| DOI | 10.1016/j.bbalip.2018.11.010 |
| 英文摘要 | Lipid homeostasis is important for executing normal cellular functions and maintaining physiological conditions. The biophysical properties and intricate metabolic network of lipids underlie the coordinated regulation of different lipid species in lipid homeostasis. To reveal the homeostatic response among different lipids, we systematically knocked down 40 lipid metabolism genes in Drosophila S2 cells by RNAi and profiled the lipidomic changes. Clustering analyses of lipids reveal that many pairs of genes acting in a sequential fashion or sharing the same substrate are tightly clustered. Through a lipid-gene regulatory network analysis, we further found that a reduction of triacylglycerol (TAG) is associated with an increase of phosphatidylinositol (PI) and lysophosphatidylinositol (LPI) or a reduction of hexosyl-ceramide (HexCer) and hydroxylated hexosyl-ceramide (OH-HexCer). Importantly, negative coregulation between TAG and LPI/PI, and positive coregulation between TAG and HexCer, were also found in human Hela cells. Together, our results reveal coregulations of TAG with PI/LPI and with HexCer in lipid homeostasis. |
| 资助项目 | National Basic Research Program of China[2016YFA0500100/2018YFA0506902] ; National Natural Science Foundation of China[91730301] ; National Natural Science Foundation of China[31571377] ; National Natural Science Foundation of China[31630019] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB13030300/0400] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000456224700006 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.amss.ac.cn/handle/2S8OKBNM/32271]  |
| 专题 | 应用数学研究所 |
| 通讯作者 | Shui, Guanghou; Wang, Yong; Huang, Xun |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Mol Dev Biol, Inst Genet & Dev Biol, Beijing 100101, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Acad Math & Syst Sci, CEMS, NCMIS,MDIS, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Ctr Excellence Anim Evolut & Genet, Kunming 650223, Yunnan, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Wei,Xin, Jingxue,Yang, Xiao,et al. Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide[J]. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,2019,1864(2):168-180. |
| APA | Wang, Wei.,Xin, Jingxue.,Yang, Xiao.,Lam, Sin Man.,Shui, Guanghou.,...&Huang, Xun.(2019).Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide.BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS,1864(2),168-180. |
| MLA | Wang, Wei,et al."Lipid-gene regulatory network reveals coregulations of triacylglycerol with phosphatidylinositol/lysophosphatidylinositol and with hexosyl-ceramide".BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1864.2(2019):168-180. |
入库方式： OAI收割
来源：数学与系统科学研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。