Engineering Magnetosomes for High-Performance Cancer Vaccination
文献类型：期刊论文
| 作者 | Li, Feng1; Nie, Weidong1; Zhang, Fan1; Lu, Guihong1; Lv, Chengliang1; Lv, Yanlin2; Bao, Weier2,3; Zhang, Lijun2,3; Wang, Shuang2; Gao, Xiaoyong2 |
| 刊名 | ACS CENTRAL SCIENCE
 |
| 出版日期 | 2019-05-22 |
| 卷号 | 5期号:5页码:796-807 |
| ISSN号 | 2374-7943 |
| DOI | 10.1021/acscentsci.9b00060 |
| 英文摘要 | A novel cancer vaccine is developed by using Fe3O4 magnetic nanoclusters (MNCs) as the core and cancer cell membranes decorated with anti-CD205 as the cloak. Because of the superparamagnetism and magnetization of MNCs, it is first achieved for the magnetic retention of vaccine in the lymph nodes with a magnetic resonance imaging (MRI) guide, which opened the time window for antigen uptake by dendritic cells (DCs). Meanwhile, the camouflaged cancer cell membranes serve as a reservoir of various antigens, enabling subsequent multiantigenic response. Additionally, the decorated anti-CD205 direct more vaccine into CD8(+) DCs, facilitating the major histocompatibility complex (MHC) I cross-presentation. These unique advantages together lead to a great proliferation of T cells with superior clonal diversity and cytotoxic activity. As a result, potent prophylactic and therapeutic effects with few abnormalities are observed on five different tumor models. Therefore, such a cancer-derived magnetosome with the integration of various recent nanotechnologies successfully demonstrates its promise for safe and high-performance cancer vaccination. |
| WOS关键词 | LIPID-A MPLA ; SYNTHETIC VACCINES ; IMMUNE-RESPONSES ; DENDRITIC CELLS ; ADJUVANT ; DNA ; CHALLENGES ; INFLUENZA ; NODE |
| 资助项目 | National Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[21821005] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000468624100012 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/28189]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wei, Wei; Xie, Hai-Yan |
| 作者单位 | 1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Feng,Nie, Weidong,Zhang, Fan,et al. Engineering Magnetosomes for High-Performance Cancer Vaccination[J]. ACS CENTRAL SCIENCE,2019,5(5):796-807. |
| APA | Li, Feng.,Nie, Weidong.,Zhang, Fan.,Lu, Guihong.,Lv, Chengliang.,...&Xie, Hai-Yan.(2019).Engineering Magnetosomes for High-Performance Cancer Vaccination.ACS CENTRAL SCIENCE,5(5),796-807. |
| MLA | Li, Feng,et al."Engineering Magnetosomes for High-Performance Cancer Vaccination".ACS CENTRAL SCIENCE 5.5(2019):796-807. |
入库方式： OAI收割
来源：过程工程研究所
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