Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics
文献类型：期刊论文
| 作者 | Lu, Guihong1; Lv, Chengliang1; Bao, Weier2; Li, Feng1; Zhang, Fan1; Zhang, Lijun2; Wang, Shuang2; Gao, Xiaoyong2; Zhao, Dongxu1; Wei, Wei2 |
| 刊名 | CHEMICAL SCIENCE
 |
| 出版日期 | 2019-05-14 |
| 卷号 | 10期号:18页码:4847-4853 |
| ISSN号 | 2041-6520 |
| DOI | 10.1039/c9sc00324j |
| 英文摘要 | Although the antimonene (AM) nanomaterial is recently emerging as a new photothermal therapy (PTT) agent, its rapid degradation in physiological medium immensely limits its direct utilization. To this end, we herein engineered AM by the cooperation of dimension optimization, size control, and cell membrane (CM) camouflage. Compared with traditional AM nanosheets, the resulting AM nanoparticles (similar to 55 nm) cloaked with the CM (denoted as CmNPs) exhibited significantly improved stability and increased photothermal efficacy as well as superior tumor targeting capacity. After intravenous injection, the CmNPs enabled satisfactory photoacoustic/ photothermal multimodal imaging at tumor sites. Meanwhile, the PTT together with the newly explored function of photodynamic therapy (PDT) achieved a potent combination therapy with few side effects. The maximized theranostic performance thus strongly recommends CmNPs as a safe and highly reliable modality for anticancer therapy. |
| WOS关键词 | CLEARANCE ABC PHENOMENON ; OXIDE NANOPARTICLES ; BLACK PHOSPHORUS ; THERAPY ; SIZE |
| 资助项目 | National Natural Science Foundation of China[81571813] ; National Natural Science Foundation of China[21874011] ; National Natural Science Foundation of China[21622608] ; National Science and Technology Major Project[2018ZX 10301405-001] ; National Key R&D Program of China[2017YFA0207900] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | ROYAL SOC CHEMISTRY |
| WOS记录号 | WOS:000468818700011 |
| 资助机构 | National Natural Science Foundation of China ; National Science and Technology Major Project ; National Key R&D Program of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/28203]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wei, Wei; Xie, Hai-yan |
| 作者单位 | 1.Beijing Inst Technol, Sch Life Sci, 5 South Zhong Guan Cun St, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 North 2nd St, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Guihong,Lv, Chengliang,Bao, Weier,et al. Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics[J]. CHEMICAL SCIENCE,2019,10(18):4847-4853. |
| APA | Lu, Guihong.,Lv, Chengliang.,Bao, Weier.,Li, Feng.,Zhang, Fan.,...&Xie, Hai-yan.(2019).Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics.CHEMICAL SCIENCE,10(18),4847-4853. |
| MLA | Lu, Guihong,et al."Antimonene with two-orders-of-magnitude improved stability for high-performance cancer theranostics".CHEMICAL SCIENCE 10.18(2019):4847-4853. |
入库方式： OAI收割
来源：过程工程研究所
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