Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics
文献类型：期刊论文
| 作者 | Wang, Dan1,2; Xie, Wensheng1,2; Gao, Qin1,2; Yan, Hao1,2; Zhang, Junxin1,2; Lu, Jingsong1,2,3; Liaw, BorShuang1,2; Guo, Zhenhu1,2; Gao, Fei1,2,4; Yin, Lan1,2 |
| 刊名 | SMALL
 |
| 出版日期 | 2019-04-18 |
| 卷号 | 15期号:16页码:11 |
| 关键词 | cancer comprehensive treatment CT images liquid metal magnetic hyperthermia stimulus-responsive drug delivery |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201900511 |
| 英文摘要 | Transformable liquid metal (LM)-based materials have attracted considerable research interest in biomedicine. However, the potential biomedical applications of LMs have not yet been fully explored. Herein, for the first trial, the inductive heating property of gallium-indium eutectic alloy (EGaIn) under alterative magnetic field is systematically investigated. By virtue of its inherent metallic nature, LM possesses excellent magnetic heating property as compared to the conventional magnetite nanoparticles, therefore enabling its unique application as non-magnetic agents in magnetic hyperthermia. Moreover, the extremely high surface tension of LM could be dramatically lowered by a rather facile PEGylation approach, making LM an ideal carrier for other theranostic cargos. By incorporating doxorubicin (DOX)-loaded mesoporous silica (DOX-MS) within PEGylated LM, a magnetic field-driven transformable LM hybrid platform capable of pH/AFM dual stimuli-responsive drug release and magnetic thermochemotherapy are successfully fabricated. The potential application for breast cancer treatment is demonstrated. Furthermore, the large X-ray attenuation ability of LM endows the hybrid with the promising ability for CT imaging. This work explores a new biomedical use of LM and a promising cancer treatment protocol based on LM hybrid for magnetic hyperthermia combined with dual stimuli-responsive chemotherapy and CT imaging. |
| WOS关键词 | INTERSTITIAL HYPERTHERMIA ; NANOPARTICLES ; BIOMATERIALS ; ELECTRODES |
| 资助项目 | National Natural Science Foundation of China[81671829] ; National Natural Science Foundation of China[51673107] ; Intergovernmental Cooperation in Science and Technology, Ministry of Science and Technology of China[2016YFE0125300] ; National Key R&D Program of China[2018YFC1106402] ; National Key R&D Program of China[2018YFA0108202] ; Fund of Key Laboratory of Advanced Materials of Ministry of Education |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000467263300013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China ; Intergovernmental Cooperation in Science and Technology, Ministry of Science and Technology of China ; National Key R&D Program of China ; Fund of Key Laboratory of Advanced Materials of Ministry of Education |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/28235]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Guifeng; Zhao, Lingyun |
| 作者单位 | 1.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China 2.Tsinghua Univ, Sch Mat Sci & Engn, Minist Educ China, Key Lab Adv Mat, Beijing 100084, Peoples R China 3.Zhejiang Univ Technol, Coll Mat Sci & Engn, Res Ctr Magnet & Elect Mat, Hangzhou 310014, Zhejiang, Peoples R China 4.Northwest Univ, Coll Chem & Mat Sci, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Xian 710069, Shaanxi, Peoples R China 5.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Dan,Xie, Wensheng,Gao, Qin,et al. Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics[J]. SMALL,2019,15(16):11. |
| APA | Wang, Dan.,Xie, Wensheng.,Gao, Qin.,Yan, Hao.,Zhang, Junxin.,...&Zhao, Lingyun.(2019).Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics.SMALL,15(16),11. |
| MLA | Wang, Dan,et al."Non-Magnetic Injectable Implant for Magnetic Field-Driven Thermochemotherapy and Dual Stimuli-Responsive Drug Delivery: Transformable Liquid Metal Hybrid Platform for Cancer Theranostics".SMALL 15.16(2019):11. |
入库方式： OAI收割
来源：过程工程研究所
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