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Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy

文献类型：期刊论文

作者Shen, Qi1,2; Yang, Jun1; Liu, Ruiyuan1; Liu, Linying1; Zhang, Jinchao2; Shen, Shigang2; Zhang, Xin1
刊名MATERIALS HORIZONS
出版日期2019-04-01
卷号6期号:4页码:810-816
ISSN号2051-6347
DOI10.1039/c8mh01286e
英文摘要A hybrid clusterbomb' as a multifunctional nanoplatform (MPSDP-ZnO/Ag) was developed for the combined immunotherapy of intracranial tumors. MPSDP-ZnO/Ag possessed high antigen loading and well-defined hybrid nanostructures, and could trigger the cluster to bomb' in response to antigen-presenting cells for simultaneous antigen and adjuvant release. The in vitro and in vivo results confirmed significant antigen accumulation and enhanced cellular and humoral immunity. More importantly, our nanovaccines obviously prolonged the survival time of tumor-bearing mice without systemic toxicity.
WOS关键词DELIVERY ; VACCINE ; SYSTEM ; NANOVACCINE ; MICELLES ; BARRIER ; CELLS
资助项目National High Technology Research and Development Program[2016YFA-0200303] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[51573188] ; National Natural Science Foundation of China[31522023] ; "Strategic Priority Research Program'' of the Chinese Academy of Sciences[XDA09030301-3] ; Beijing Municipal Science & Technology Commission[Z161100002616015] ; Beijing Natural Science Foundation[L172046]
WOS研究方向Chemistry ; Materials Science
语种英语
WOS记录号WOS:000466314400013
出版者ROYAL SOC CHEMISTRY
资助机构National High Technology Research and Development Program ; National Natural Science Foundation of China ; "Strategic Priority Research Program'' of the Chinese Academy of Sciences ; Beijing Municipal Science & Technology Commission ; Beijing Natural Science Foundation
源URL[http://ir.ipe.ac.cn/handle/122111/28261]  
专题中国科学院过程工程研究所
通讯作者Shen, Shigang; Zhang, Xin
作者单位1.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
2.Hebei Univ, Coll Chem & Environm Sci, Baoding 071002, Peoples R China
推荐引用方式
GB/T 7714		 Shen, Qi,Yang, Jun,Liu, Ruiyuan,et al. Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy[J]. MATERIALS HORIZONS,2019,6(4):810-816.
APA Shen, Qi.,Yang, Jun.,Liu, Ruiyuan.,Liu, Linying.,Zhang, Jinchao.,...&Zhang, Xin.(2019).Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy.MATERIALS HORIZONS,6(4),810-816.
MLA Shen, Qi,et al."Hybrid "clusterbombs' as multifunctional nanoplatforms potentiate brain tumor immunotherapy".MATERIALS HORIZONS 6.4(2019):810-816.

入库方式： OAI收割

来源：过程工程研究所

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