Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells
文献类型：期刊论文
| 作者 | Shao, Jingxin1; Pijpers, Imke A. B.1; Cao, Shoupeng1; Williams, David S.2; Yan, Xuehai3; Li, Junbai4; Abdelmohsen, Loai K. E. A.1; van Hest, Jan C. M.1 |
| 刊名 | ADVANCED SCIENCE
 |
| 出版日期 | 2019-03-06 |
| 卷号 | 6期号:5页码:8 |
| 关键词 | biomorphic engineering cell-mimetic erythrocytes hypoxia stomatocytes |
| ISSN号 | 2198-3844 |
| DOI | 10.1002/advs.201801678 |
| 英文摘要 | Morphologically discrete nanoarchitectures, which mimic the structural complexity of biological systems, are an increasingly popular design paradigm in the development of new nanomedical technologies. Herein, engineered polymeric stomatocytes are presented as a structural and functional mimic of red blood cells (RBCs) with multifunctional therapeutic features. Stomatocytes, comprising biodegradable poly(ethylene glycol) block-poly(D,L-lactide), possess an oblate-like morphology reminiscent of RBCs. This unique dual-compartmentalized structure is augmented via encapsulation of multifunctional cargo (oxygen-binding hemoglobin and the photosensitizer chlorin e6). Furthermore, stomatocytes are decorated with a cell membrane isolated from erythrocytes to ensure that the surface characteristics matched those of RBCs. In vivo biodistribution data reveal that both the uncoated and coated nano-RBCs have long circulation times in mice, with the membrane-coated ones outperforming the uncoated stomatoctyes. The capacity of nano-RBCs to transport oxygen and create oxygen radicals upon exposure to light is effectively explored toward photodynamic therapy, using 2D and 3D tumor models; addressing the challenge presented by cancer-induced hypoxia. The morphological and functional control demonstrated by this synthetic nanosystem, coupled with indications of therapeutic efficacy, constitutes a highly promising platform for future clinical application. |
| WOS关键词 | MEMBRANE-CAMOUFLAGED NANOPARTICLES ; PHOTODYNAMIC THERAPY ; TUMOR HYPOXIA ; SILICA NANOPARTICLES ; ERYTHROCYTE-MEMBRANE ; ARTIFICIAL CELLS ; CHEMICAL DESIGN ; CANCER ; DELIVERY ; OXYGEN |
| 资助项目 | ERC Advanced Grant[Artisym 694120] ; Dutch Ministry of Education, Culture and Science[024.001.035] ; China Scholarship Council ; European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie Innovative Training Networks (ITN) Nanomed[676137] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000460374300014 |
| 出版者 | WILEY |
| 资助机构 | ERC Advanced Grant ; Dutch Ministry of Education, Culture and Science ; China Scholarship Council ; European Union's Horizon 2020 research and innovation programme Marie Sklodowska-Curie Innovative Training Networks (ITN) Nanomed |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/28300]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Abdelmohsen, Loai K. E. A.; van Hest, Jan C. M. |
| 作者单位 | 1.Eindhoven Univ Technol, Inst Complex Mol Syst, Bioorgan Chem, Helix,Kranenveld STO 3-41,POB 513, NL-5600 MB Eindhoven, Netherlands 2.Swansea Univ, Coll Sci, Dept Chem, Swansea SA2 8PP, W Glam, Wales 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Chinese Acad Sci, Inst Chem, CAS Key Lab Colloid Interface & Chem Thermodynam, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Shao, Jingxin,Pijpers, Imke A. B.,Cao, Shoupeng,et al. Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells[J]. ADVANCED SCIENCE,2019,6(5):8. |
| APA | Shao, Jingxin.,Pijpers, Imke A. B..,Cao, Shoupeng.,Williams, David S..,Yan, Xuehai.,...&van Hest, Jan C. M..(2019).Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells.ADVANCED SCIENCE,6(5),8. |
| MLA | Shao, Jingxin,et al."Biomorphic Engineering of Multifunctional Polylactide Stomatocytes toward Therapeutic Nano-Red Blood Cells".ADVANCED SCIENCE 6.5(2019):8. |
入库方式： OAI收割
来源：过程工程研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。