In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers
文献类型：期刊论文
| 作者 | Zhang, Jun1; Wang, Ying1; Zhang, Shan1; You, Guo-Xing1; Li, Peng-Long1; Wang, Quan1; Yu, Wei-Li2; Hu, Tao2; Zhou, Hong1; Zhao, Lian1 |
| 刊名 | ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
 |
| 出版日期 | 2018 |
| 卷号 | 46页码:S133-S137 |
| 关键词 | HBOCs Dex-bHb blood compatibility organ protection |
| ISSN号 | 2169-1401 |
| DOI | 10.1080/21691401.2018.1489273 |
| 英文摘要 | The development of hemoglobin-based oxygen carriers (HBOCs) is a persistent and urgent need in biomedicine. As a potential HBOCs, Dextran-hemoglobin (Dex-bHb) has been developed over the past years. The novel Dex-bHb, whose thiol group of Cys-93(beta) was reversibly protected, was produced and the characteristics were evaluated in our previous study. Herein, blood compatibility was characterized in terms of the red blood cell aggregation and hemolysis rate in vitro, and Dex-bHb showed no obvious effects. After intravenous administration of Dex-bHb to golden Syrian hamsters with hemorrhages shock, it showed mean arterial pressure recovery, blood flow increase and the organ protection from serious hemorrhage injury. Consequently, Dex-bHb is hopeful to be a safe and available blood substitute. |
| WOS关键词 | BLOOD SUBSTITUTES ; HEMOGLOBIN ; DEXTRAN ; RESUSCITATION ; BINDING |
| 资助项目 | National Natural Science Foundation of China[81700181] ; National Natural Science Foundation of China[81600148] |
| WOS研究方向 | Biotechnology & Applied Microbiology ; Engineering ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000460141900013 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/28632]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Hu, Tao; Zhou, Hong; Zhao, Lian |
| 作者单位 | 1.Acad Mil Med Sci, Inst Hlth Serv & Transfus Med, Beijing, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Jun,Wang, Ying,Zhang, Shan,et al. In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers[J]. ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,2018,46:S133-S137. |
| APA | Zhang, Jun.,Wang, Ying.,Zhang, Shan.,You, Guo-Xing.,Li, Peng-Long.,...&Zhao, Lian.(2018).In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers.ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY,46,S133-S137. |
| MLA | Zhang, Jun,et al."In vitro and in vivo investigation of the novel Dex-bHb as oxygen carriers".ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY 46(2018):S133-S137. |
入库方式： OAI收割
来源：过程工程研究所
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