Hierarchical assembled nanomaterial paper based analytical devices for simultaneously electrochemical detection of microRNAs
文献类型：期刊论文
| 作者 | Tian, Rong1,2,3; Li, Yujing4; Bai, Jingwei1 |
| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2019-06-13 |
| 卷号 | 1058页码:89-96 |
| 关键词 | Paper device MOFs MicroRNA Simultaneous detection |
| ISSN号 | 0003-2670 |
| DOI | 10.1016/j.aca.2019.01.036 |
| 通讯作者 | Tian, Rong(rtian2017@tsinghua.edu.cn) ; Bai, Jingwei(jingwbai@mail.tsinghua.edu.cn) |
| 英文摘要 | Paper based biosensor devices have the benefit of easy-use, low-cost and environmental friendly for point-of-care diagnostic application. In this research, we report a novel form of paper based biosensor with hierarchical assembled nanomaterials and MOF enhanced bio-probes for the simultaneous detection of microRNA-141 (miR-141) and microRNA-21 (miR-21) which have the potential for early cancer detection. The combination of multi-dimensional nanomaterial allows low impedance and high sensing area on typical poorly defined paper substrate. MOF conjugated bio-probe, methylene blue (MB) and ferrocene (Fc) with distinguishable electrochemical signal, further contributed to the high selectivity and sensitivity. Simultaneously detection of miR-141 and miR-21 with a detection limit of 0.1 fM was demonstrated under optimal conditions. All these features enable accurately target detection in serum samples. Therefore, this strategy is of promising as an inexpensive, easy access diagnosis platform for cancers by means of simultaneously detection of a variety of miRNA biomarkers. (C) 2019 Elsevier B.V. All rights reserved. |
| 资助项目 | Tsinghua-Peking Joint Center for Life Sciences Post-doctoral Fund |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000460376500010 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/7546]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Tian, Rong; Bai, Jingwei |
| 作者单位 | 1.Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China 2.Tsinghua Peking Joint Ctr Life Sci, Beijing 100084, Peoples R China 3.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Beijing, Peoples R China 4.Beijing Inst Technol, Mat Inst, Beijing 100081, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Rong,Li, Yujing,Bai, Jingwei. Hierarchical assembled nanomaterial paper based analytical devices for simultaneously electrochemical detection of microRNAs[J]. ANALYTICA CHIMICA ACTA,2019,1058:89-96. |
| APA | Tian, Rong,Li, Yujing,&Bai, Jingwei.(2019).Hierarchical assembled nanomaterial paper based analytical devices for simultaneously electrochemical detection of microRNAs.ANALYTICA CHIMICA ACTA,1058,89-96. |
| MLA | Tian, Rong,et al."Hierarchical assembled nanomaterial paper based analytical devices for simultaneously electrochemical detection of microRNAs".ANALYTICA CHIMICA ACTA 1058(2019):89-96. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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