Use of biological detection methods to assess dioxin-like compounds in sediments of Bohai Bay, China
文献类型：期刊论文
| 作者 | Dong, Wenjing1; Wang, Feng1; Fang, Mingliang2; Wu, Jie1; Wang, Shuaiyu1; Li, Ming1; Yang, Jingfeng1; Chernick, Melissa3; Hinton, David E.3; Pei, De-Sheng4
|
| 刊名 | ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
 |
| 出版日期 | 2019-05-30 |
| 卷号 | 173页码:339-346 |
| 关键词 | Zebrafish Marine sediments cYP1A AhR2 pathway Bioassessment |
| ISSN号 | 0147-6513 |
| DOI | 10.1016/j.ecoenv.2019.01.116 |
| 通讯作者 | Mu, Jingli(jlmu@mju.edu.cn) ; Xie, Lingtian(lingtian.xie@m.scnu.edu.cn) ; Dong, Wu(dongwu@imun.edu.cn) |
| 英文摘要 | Bohai Bay, in the western region of northeastern China's Bohai Sea, receives water from large rivers containing various pollutants including dioxin-like compounds (DLCs). This study used the established zebrafish (Danio rerio) model, its known developmental toxicity endpoints and sensitive molecular analyses to evaluate sediments near and around an industrial effluent site in Bohai Bay. The primary objective was to assess the efficacy of rapid biological detection methods as an addition to chemical analyses. Embryos were exposed to various concentrations of sediment extracts as well as a 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin (TCDD) positive control. Exposure to sediment extract nearest the discharge site (P1) resulted in the most severe- and highest rates of change in embryos and larvae, suggesting that DLC contaminated sediment probably did not occur much beyond it. P1 extract resulted in concentration dependent increases in mortality and pericardial edema. Its highest concentration caused up-regulation of P-450 (CYP)-1A1(CYP1A) mRNA expression at 72 h post fertilization (hpf), an increase in its expression in gill arches as observed by whole mount in situ hybridization, and an increased signal in the Tg(cyp1a: mCherry) transgenic line. The pattern and magnitude of response was very similar to that of TCDD and supported the presence of DLCs in these sediment samples. Follow-up chemical analysis confirmed this presence and identified H7CDF, O8CDF and O8CDD as the main components in P1 extract. This study validates the use of biological assays as a rapid, sensitive, and cost-effective method to evaluate DLCs and their effects in sediment samples. Additionally, it provides support for the conclusion that DLCs have limited remobilization capacity in marine sediments. |
| 资助项目 | National Natural Science Foundation of China[21267015] ; National Natural Science Foundation of China[21567019] ; National Natural Science Foundation of China[81360508] ; National Natural Science Foundation of China[41807352] ; National Natural Science Foundation of China[41877366] ; National Natural Science Foundation of China[641722110] ; National Natural Science Foundation of China[41571474] ; Inner Mongolia University for Nationalities, China[MDXK008] ; Open Project Program of Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, China[MDK2017012] ; Open Project Program of Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, China[MDK2017014] ; Open Project Program of Inner Mongolia Key Laboratory of Toxicant Monitoring and Toxicology, China[MDK2018027] ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing, China[CSTCCXLJRC201714] |
| WOS研究方向 | Environmental Sciences & Ecology ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000463462800038 |
| 出版者 | ACADEMIC PRESS INC ELSEVIER SCIENCE |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/7767]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 通讯作者 | Mu, Jingli; Xie, Lingtian; Dong, Wu |
| 作者单位 | 1.Inner Mongolia Univ Nationalities, Coll Anim Sci & Technol, Inner Mongolia Key Lab Toxicant Monitoring & Toxi, Tongliao 028000, Peoples R China 2.Nanyang Technol Univ, Sch Civil & Environm Engn, 50 Nanyang Ave, Singapore 639798, Singapore 3.Duke Univ, Nicholas Sch Environm, Durham, NC 27708 USA 4.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 5.South China Normal Univ, SCNU Environm Res Inst, Guangdong Prov Key Lab Chem Pollut & Environm Saf, Guangzhou 510006, Guangdong, Peoples R China 6.South China Normal Univ, MOE Key Lab Environm Theoret Chem, Guangzhou 510006, Guangdong, Peoples R China 7.Jilin Univ, Coll Environm & Resources, Minist Educ, Key Lab Groundwater Resources & Environm, Jilin 130021, Jilin, Peoples R China 8.Minjiang Univ, Inst Oceanog, Fuzhou 350108, Fujian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Dong, Wenjing,Wang, Feng,Fang, Mingliang,et al. Use of biological detection methods to assess dioxin-like compounds in sediments of Bohai Bay, China[J]. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,2019,173:339-346. |
| APA | Dong, Wenjing.,Wang, Feng.,Fang, Mingliang.,Wu, Jie.,Wang, Shuaiyu.,...&Dong, Wu.(2019).Use of biological detection methods to assess dioxin-like compounds in sediments of Bohai Bay, China.ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY,173,339-346. |
| MLA | Dong, Wenjing,et al."Use of biological detection methods to assess dioxin-like compounds in sediments of Bohai Bay, China".ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 173(2019):339-346. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。