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Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish

文献类型：期刊论文

作者Deng, Shun1,2; Fu, Ailing2; Junaid, Muhammad1,3; Wang, Yan1,3; Yin, Qian1; Fu, Chen2; Liu, Li1,3; Su, Dong-Sheng1; Bian, Wan-Ping1,3; Pei, De-Sheng1,3
刊名BIOMATERIALS
出版日期2019-06-01
卷号206页码:61-72
关键词Danio rerio N-GQDs Redox system Antioxidant enzyme activity USGO
ISSN号0142-9612
DOI10.1016/j.biomaterials.2019.03.028
通讯作者Pei, De-Sheng(peids@cigit.ac.cn)
英文摘要Graphene quantum dots (GQDs) are well-known for its potential applications for bioimaging, biosensor, and drug carrier in biomedicine. GQDs are well characteristic of intrinsic peroxidase-like catalytic activity, which is proven effective in scavenging the free radicals, such assuperoxide anion, hydrogen peroxide, and hydroxyl radical. GQDs are also well praised for its low in vivo and in vitro toxicity. Here, we found that nitrogen-doped GQDs (N-GQDs) can strongly disturb redox-sensitive system via the selective inhibition of endogenous antioxidant enzyme activities in zebrafish. The enzyme activities or transcription levels of a battery of hemoproteins including catalase (CAT), superoxide dismutase (SOD), respiratory chain complex I, complex III, hemoglobin (Hb), and myeloperoxidase (MPO), were significantly suppressed by N-GQDs. We also found that N-GQDs activated the cytochrome P450 monooxygenase (e.g. cyp1a) and the associated aryl-hydrocarbon receptor repressors (ahrr1 and ahrr2) in zebrafish embryos. Compared to the ultrasmall graphene oxide (USGO), N-GQDs exhibited stronger fluorescent permeability and tissue-specific bio-accumulative effects. Taken together, our findings highlighted that exposure to N-GQDs can disrupt endogenous antioxidant enzyme activities, possibly via the competitive inhibition of electron transfer process. Our results in this study provided solid data for biosafety evaluations of various types of GQDs, and created an alert for the future biomedical applications of N-GQDs.
资助项目CAS Team Project of the Belt and Road ; Three Hundred Leading Talents in Scientific and Technological Innovation Program of Chongqing[CSTCCXLJRC201714]
WOS研究方向Engineering ; Materials Science
语种英语
WOS记录号WOS:000467669700006
出版者ELSEVIER SCI LTD
源URL[http://119.78.100.138/handle/2HOD01W0/7794]  
专题环境与健康研究中心
通讯作者Pei, De-Sheng
作者单位1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Key Lab Reservoir Aquat Environm, Chongqing 400714, Peoples R China
2.Southwest Univ, Coll Pharmaceut Sci, Chongqing 400715, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Deng, Shun,Fu, Ailing,Junaid, Muhammad,et al. Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish[J]. BIOMATERIALS,2019,206:61-72.
APA Deng, Shun.,Fu, Ailing.,Junaid, Muhammad.,Wang, Yan.,Yin, Qian.,...&Pei, De-Sheng.(2019).Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish.BIOMATERIALS,206,61-72.
MLA Deng, Shun,et al."Nitrogen-doped graphene quantum dots (N-GQDs) perturb redox-sensitive system via the selective inhibition of antioxidant enzyme activities in zebrafish".BIOMATERIALS 206(2019):61-72.

入库方式： OAI收割

来源：重庆绿色智能技术研究院

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