Graphene Nanoplatelets-Based Aptamer Biochip for the Detection of Lipocalin-2
文献类型：会议论文
| 作者 | Matassan, Nur Diyanah1; Rizwan, Mohammad1; Mohd-Naim, Noor Faizah1,2; Tlili, Chaker2 ; Ahmed, Minhaz Uddin1
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| 出版日期 | 2018 |
| 会议日期 | October 28, 2018 - October 31, 2018 |
| 会议地点 | New Delhi, India |
| DOI | 10.1109/ICSENS.2018.8589938 |
| 英文摘要 | An electrochemical aptasensor platform was developed by using amine-functionalized aptamer that was incorporated onto carbon-printed electrode and modified with graphene nanoplatelets for the detection of lipocalin-2 (LCN-2) protein. The aptamers were covalently bound to the graphene nanoplatelets surface via 1-Ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC) and N-hydroxysuccinimide (NHS) chemistry and were used as the molecular recognition element for the protein target. Successful interaction between aptamer and LCN-2 protein was ascertained via electrochemical probe, ferro- and ferri-cyanide, Fe(CN)63-/4-, and monitored by means of voltammetric analyses. The developed LCN-2 aptasensor achieved sub-picomolar detection of protein, with the detection limit determined as 0.07 pg ml-1, and a dynamic linear range of 0.1 to 1000 pg ml-1. © 2018 IEEE. |
| 会议录 | 17th IEEE SENSORS Conference, SENSORS 2018
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| 语种 | 英语 |
| 电子版国际标准刊号 | 21689229 |
| ISSN号 | 19300395 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/7970]  |
| 专题 | 中国科学院重庆绿色智能技术研究院 |
| 作者单位 | 1.Faculty of Science, IBiosensors and Biotechnology Laboratory, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong; BE1410, Brunei; 2.Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Fangzheng Avenue, Shuitu Hi-tech Industrial Park, Chongqing, China |
| 推荐引用方式 GB/T 7714 | Matassan, Nur Diyanah,Rizwan, Mohammad,Mohd-Naim, Noor Faizah,et al. Graphene Nanoplatelets-Based Aptamer Biochip for the Detection of Lipocalin-2[C]. 见:. New Delhi, India. October 28, 2018 - October 31, 2018. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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