Potential adverse outcome pathway (AOP) of silver nanoparticles mediated reproductive toxicity in zebrafish
文献类型：期刊论文
| 作者 | Ma, Yan-Bo1 ; Lu, Chun-Jiao1; Junaid, Muhammad1,2; Jia, Pan-Pan1,2; Yang, Li1; Zhang, Jing-Hui1; Pei, De-Sheng1
|
| 刊名 | Chemosphere
 |
| 出版日期 | 2018 |
| 卷号 | 207页码:320-328 |
| ISSN号 | 00456535 |
| DOI | 10.1016/j.chemosphere.2018.05.019 |
| 英文摘要 | Recently, the augmented utilization of silver nanoparticles (AgNPs) resulted in increasingrates of its release to aquatic environment, which potentially caused adverse effects to aquatic organisms. Therefore, this study investigated - reproductive toxicity and associated potential adverse outcome pathway (AOP) in zebrafish after chronic exposure to AgNPs. To serve the purpose, three-month-old adult zebrafish were exposed to different concentrations (0, 10, 33 and 100 μg/L) of AgNPs for five weeks. Exposure to 33 and 100 μg/L of AgNPs significantly decreased the fecundity in female zebrafish, accompanied by increasing apoptotic cells in the ovarian and testicular tissue using TUNEL assay. Increasing tissue burdens of AgNPs and reactive oxygen species (ROS) production were also found in both ovary and testis after five-week exposure to AgNPs. To explore the mechanism of the apoptotic pathway, the transcription levels of various genes (bax, bcl-2, caspase-3, and caspase-9) associated with the mitochondrion-mediated apoptosis pathway were examined in zebrafish after exposure to AgNPs. The results showed that the expression patterns of all the investigated genes were altered to some extent. These findings demonstrated that AgNPs exposure caused oxidative stress, induced germ cells apoptosis via mitochondrial-dependent pathway, and ultimately impaired the reproduction in zebrafish. © 2018 Elsevier Ltd |
| 电子版国际标准刊号 | 18791298 |
| 语种 | 英语 |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/8036]  |
| 专题 | 环境与健康研究中心 |
| 作者单位 | 1.Key Laboratory of Reservoir Aquatic Environment, Chongqing Institute of Green and Intelligent Technology, Chinese Academy of Sciences, Chongqing; 400714, China; 2.University of Chinese Academy of Sciences, Beijing; 100049, China |
| 推荐引用方式 GB/T 7714 | Ma, Yan-Bo,Lu, Chun-Jiao,Junaid, Muhammad,et al. Potential adverse outcome pathway (AOP) of silver nanoparticles mediated reproductive toxicity in zebrafish[J]. Chemosphere,2018,207:320-328. |
| APA | Ma, Yan-Bo.,Lu, Chun-Jiao.,Junaid, Muhammad.,Jia, Pan-Pan.,Yang, Li.,...&Pei, De-Sheng.(2018).Potential adverse outcome pathway (AOP) of silver nanoparticles mediated reproductive toxicity in zebrafish.Chemosphere,207,320-328. |
| MLA | Ma, Yan-Bo,et al."Potential adverse outcome pathway (AOP) of silver nanoparticles mediated reproductive toxicity in zebrafish".Chemosphere 207(2018):320-328. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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