Investigation of the adsorption behavior of BSA with tethered lipid layer-modified solid-state nanopores in a wide pH range
文献类型：期刊论文
| 作者 | Tian, Haibing1,2; Xie, Wanyi1,2 ; He, Shixuan1; Zhou, Daming1; Fang, Shaoxi1; Liang, Liyuan1,2; Wang, Deqiang1,2
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| 刊名 | RSC ADVANCES
 |
| 出版日期 | 2019-05-19 |
| 卷号 | 9期号:27页码:15431-15436 |
| ISSN号 | 2046-2069 |
| DOI | 10.1039/c9ra00698b |
| 通讯作者 | Liang, Liyuan() ; Wang, Deqiang(dqwang@cigit.ac.cn) |
| 英文摘要 | Nanopore technology was introduced for the study of the dynamic interactions between bovine serum albumin (BSA) and 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE) phospholipids based on a modified nanopore. The results reveal that the interaction mechanism between DOPE and BSA is affected by the pH of the subphase. Far above the BSA isoelectric point (pH > 7), a weaker hydrophobic interaction and stronger electrostatic repulsion exist between the DOPE and BSA molecules. At pH = 7, the BSA structure nearly does not change, and the interaction is weak. At pH 5 and pH 6, BSA is marginally affected by the adsorption interaction, and below pH 5, the DOPE film becomes disordered, so there is a strong repulsive force interaction between the BSA and DOPE. |
| 资助项目 | Key Research Program of the Chinese Academy of Sciences[KFZD-SW-219] ; Natural Science Foundation of Chongqing, China[cstc2018jcyjA1467] ; Natural Science Foundation of Chongqing, China[cstc2017jcyjB0105] ; National Natural Science Foundation of China[41603089] ; National Natural Science Foundation of China[61701474] ; Youth Innovation Promotion Association[2017392] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000470161800037 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://119.78.100.138/handle/2HOD01W0/8127]  |
| 专题 | 精准医疗单分子诊断技术研究中心 |
| 通讯作者 | Liang, Liyuan; Wang, Deqiang |
| 作者单位 | 1.Chinese Acad Sci, Chongqing Inst Green & Intelligent Technol, Chongqing 400714, Peoples R China 2.Univ Chinese Acad Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Haibing,Xie, Wanyi,He, Shixuan,et al. Investigation of the adsorption behavior of BSA with tethered lipid layer-modified solid-state nanopores in a wide pH range[J]. RSC ADVANCES,2019,9(27):15431-15436. |
| APA | Tian, Haibing.,Xie, Wanyi.,He, Shixuan.,Zhou, Daming.,Fang, Shaoxi.,...&Wang, Deqiang.(2019).Investigation of the adsorption behavior of BSA with tethered lipid layer-modified solid-state nanopores in a wide pH range.RSC ADVANCES,9(27),15431-15436. |
| MLA | Tian, Haibing,et al."Investigation of the adsorption behavior of BSA with tethered lipid layer-modified solid-state nanopores in a wide pH range".RSC ADVANCES 9.27(2019):15431-15436. |
入库方式： OAI收割
来源：重庆绿色智能技术研究院
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