Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.
文献类型：期刊论文
| 作者 | Gao, Tingting1; Ma, Shuai2; Song, Jiayin3; Bi, Hongtao1; Tao, Yanduo1 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2011-11-01 |
| 卷号 | 49期号:4页码:580-586 |
| 关键词 | Aconitum Kusnezoffii Reichb. Polysaccharide Antioxidant Activity Immunological Activity |
| ISSN号 | 0141-8130 |
| 文献子类 | Article |
| 英文摘要 | Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H(2)O(2) and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved.; Aconitum kusnezoffii Reichb., one of the earliest recorded toxic species of genus Aconitum, has been used as traditional Chinese medicine and medicinal diet over the last 2500 years to treat heart failure congestion, neuralgia, rheumatism and gout, etc. In the present paper, four water-soluble polysaccharide fractions isolated from the tubers of A. kusnezoffii Reichb. were studied the antioxidant and immunological activities for the first time. In vitro antioxidant assays indicated that fraction WKCP-A had noticeable scavenging activities on DPPH radical, hydroxyl radical, superoxide anion, H2O2 and self-oxidation of 1,2,3-phentriol, ferrous ion-chelating ability and reducing power. Moreover, the in vivo immunological assay exhibited that fractions WKCP-A and WKHP could more significantly enhance splenic lymphocyte proliferation and macrophage phagocytosis than other fractions. Therefore, the water-soluble polysaccharides from A. kusnezoffii Reichb., especially WKCP-A, have the potential to be explored as novel natural antioxidants and immunostimulating agents for using in functional foods or medicine. (C) 2011 Elsevier B.V. All rights reserved. |
| WOS关键词 | GANODERMA-LUCIDUM ; OXIDATIVE STRESS ; LIPID-PEROXIDATION ; ARROW POISONS ; ASSAY ; AUTOXIDATION ; DERIVATIVES ; SUPEROXIDE ; MECHANISMS ; INHIBITORS |
| WOS研究方向 | Biochemistry & Molecular Biology |
| 语种 | 英语 |
| WOS记录号 | WOS:000295502500021 |
| 公开日期 | 2011-12-13 |
| 源URL | [http://ir.nwipb.ac.cn//handle/363003/1502]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 作者单位 | 1.Chinese Acad Sci, NW Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 130024, Qinghai Provinc, Peoples R China 2.China Med Univ, Dept Oncosurg, Affiliated Hosp 1, Shenyang 110001, Peoples R China 3.Tianjin Univ, Sch Architecture, Tianjin 300072, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gao, Tingting,Ma, Shuai,Song, Jiayin,et al. Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2011,49(4):580-586. |
| APA | Gao, Tingting,Ma, Shuai,Song, Jiayin,Bi, Hongtao,&Tao, Yanduo.(2011).Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb..INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,49(4),580-586. |
| MLA | Gao, Tingting,et al."Antioxidant and immunological activities of water-soluble polysaccharides from Aconitum kusnezoffii Reichb.".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 49.4(2011):580-586. |
入库方式： OAI收割
来源：西北高原生物研究所
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