中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau

文献类型:期刊论文

作者Zhao, Yang ; Ren, Ji-Long ; Wang, Ming-Yang ; Zhang, Sheng-Ting ; Liu, Yu ; Li, Min ; Cao, Yi-Bin ; Zu, Hu-Yue ; Chen, Xiao-Cheng ; Wu, Chung-I ; Nevo, Eviatar ; Chen, Xue-Qun ; Du, Ji-Zeng ; Du, JZ (reprint author), Zhejiang Univ, Sch Med, Dept Basic Med Sci, Div Neurobiol & Physiol, Hangzhou 310058, Zhejiang, Peoples R China.
刊名PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA ; Zhao, Y; Ren, JL; Wang, MY; Zhang, ST; Liu, Y; Li, M; Cao, YB; Zu, HY; Chen, XC; Wu, CI; Nevo, E; Chen, XQ; Du, JZ.Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(51):20639-20644
出版日期2013-12-17
英文摘要Mutational changes in p53 correlate well with tumorigenesis. Remarkably, however, relatively little is known about the role that p53 variations may play in environmental adaptation. Here we report that codon asparagine-104 (104N) and glutamic acid-104 (104E), respectively, of the p53 gene in the wild zokor (Myospalax baileyi) and root vole (Microtus oeconomus) are adaptively variable, meeting the environmental stresses of the Tibetan plateau. They differ from serine-104 (104S) seen in other rodents, including the lowland subterranean zokor Myospalax cansus, and from serine 106 (106S) in humans. Based on site-directed mutational analysis in human cell lines, the codon 104N variation in M. baileyi is responsible for the adaptive balance of the transactivation of apoptotic genes under hypoxia, cold, and acidic stresses. The 104E p53 variant in Microtus oeconomus suppresses apoptotic gene transactivation and cell apoptosis. Neither 104N nor 104E affects the cell-cycle genes. We propose that these variations in p53 codon 104 are an outcome of environmental adaptation and evolutionary selection that enhance cellular strategies for surviving the environmental stresses of hypoxia and cold (in M. baileyi and M. oeconomus) and hypercapnia (in M. baileyi) in the stressful environments of the Qinghai-Tibet plateau.; Mutational changes in p53 correlate well with tumorigenesis. Remarkably, however, relatively little is known about the role that p53 variations may play in environmental adaptation. Here we report that codon asparagine-104 (104N) and glutamic acid-104 (104E), respectively, of the p53 gene in the wild zokor (Myospalax baileyi) and root vole (Microtus oeconomus) are adaptively variable, meeting the environmental stresses of the Tibetan plateau. They differ from serine-104 (104S) seen in other rodents, including the lowland subterranean zokor Myospalax cansus, and from serine 106 (106S) in humans. Based on site-directed mutational analysis in human cell lines, the codon 104N variation in M. baileyi is responsible for the adaptive balance of the transactivation of apoptotic genes under hypoxia, cold, and acidic stresses. The 104E p53 variant in Microtus oeconomus suppresses apoptotic gene transactivation and cell apoptosis. Neither 104N nor 104E affects the cell-cycle genes. We propose that these variations in p53 codon 104 are an outcome of environmental adaptation and evolutionary selection that enhance cellular strategies for surviving the environmental stresses of hypoxia and cold (in M. baileyi and M. oeconomus) and hypercapnia (in M. baileyi) in the stressful environments of the Qinghai-Tibet plateau.
源URL[http://210.75.249.4/handle/363003/3887]  
专题西北高原生物研究所_中国科学院西北高原生物研究所
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Zhao, Yang,Ren, Ji-Long,Wang, Ming-Yang,et al. Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Zhao, Y; Ren, JL; Wang, MY; Zhang, ST; Liu, Y; Li, M; Cao, YB; Zu, HY; Chen, XC; Wu, CI; Nevo, E; Chen, XQ; Du, JZ.Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau,PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2013,110(51):20639-20644,2013.
APA Zhao, Yang.,Ren, Ji-Long.,Wang, Ming-Yang.,Zhang, Sheng-Ting.,Liu, Yu.,...&Du, JZ .(2013).Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA.
MLA Zhao, Yang,et al."Codon 104 variation of p53 gene provides adaptive apoptotic responses to extreme environments in mammals of the Tibet plateau".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013).

入库方式: OAI收割

来源:西北高原生物研究所

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