Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles
文献类型：期刊论文
| 作者 | Zhang, Yaqin ; Liu, Bin ; Wu, Heming ; Li, Bin ; Xu, Junyong ; Duan, Lei ; Jiang, Caiyun ; Zhao, Xiaohui ; Yuan, Yi ; Zhang, Gen ; Zeng, Xin |
| 刊名 | JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
 ; Zhang, YQ; Liu, B; Wu, HM; Li, B; Xu, JY; Duan, L; Jiang, CY; Zhao, XH; Yuan, Y; Zhang, G; Zeng, X.Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles,JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014,10(12):3638
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| 出版日期 | 2014-12-01 |
| 英文摘要 | Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth.; Verbascoside (VB), a major bioactive constituent of the Tsoong herb, has attracted a great deal of attention due to its pharmacological properties. In this study, we demonstrated the inhibitory effect of VB-loaded gold nanoparticles (VB-Au) on the growth of K562 cells both in vitro and in vivo. We found that, in contrast with the same concentration of gold nanoparticles (Au) or VB, VB-Au significantly decreased the viability of K562 cells and promoted the apoptosis of tumor cells. A tumor implantation mouse model further showed that the intravenous injection of VB-Au effectively inhibited the growth and induced the apoptosis of tumor cells. In conclusion, our results collectively demonstrate that VB-Au nanoparticles provide an effective strategy to control tumor cell growth. |
| 源URL | [http://210.75.249.4/handle/363003/4173]  |
| 专题 | 西北高原生物研究所_中国科学院西北高原生物研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, Yaqin,Liu, Bin,Wu, Heming,et al. Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Zhang, YQ; Liu, B; Wu, HM; Li, B; Xu, JY; Duan, L; Jiang, CY; Zhao, XH; Yuan, Y; Zhang, G; Zeng, X.Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles,JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2014,10(12):3638,2014. |
| APA | Zhang, Yaqin.,Liu, Bin.,Wu, Heming.,Li, Bin.,Xu, Junyong.,...&Zeng, Xin.(2014).Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY. |
| MLA | Zhang, Yaqin,et al."Anti-Tumor Activity of Verbascoside Loaded Gold Nanoparticles".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY (2014). |
入库方式： OAI收割
来源：西北高原生物研究所
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