Antagonistic chemical coupling in self-reconfigurable host-guest protocells
文献类型：期刊论文
| 作者 | Martin, Nicolas1,2; Douliez, Jean-Paul3; Qiao, Yan1,2,4; Booth, Richard1,2; Li, Mei1,2; Mann, Stephen1,2 |
| 刊名 | NATURE COMMUNICATIONS
 |
| 出版日期 | 2018-09-07 |
| 卷号 | 9 |
| ISSN号 | 2041-1723 |
| DOI | 10.1038/s41467-018-06087-3 |
| 英文摘要 | Fabrication of compartmentalised chemical systems with nested architectures and biomi-metic properties has important implications for controlling the positional assembly of functional components, spatiotemporal regulation of enzyme cascades and modelling of protoorganelle behaviour in synthetic protocells. Here, we describe the spontaneous capture of glucose oxidase-containing proteinosomes in pH-sensitive fatty acid micelle coacervate droplets as a facile route to multi-compartmentalised host-guest protocells capable of antagonistic chemical and structural coupling. The nested system functions co-operatively at low-substrate turnover, while high levels of glucose give rise to pH-induced disassembly of the droplets, release of the incarcerated proteinosomes and self-reconfiguration into spatially organised enzymatically active vesicle-in-proteinosome protocells. Co-encapsulation of antagonistic enzymes within the proteinosomes produces a sequence of self-induced capture and host-guest reconfiguration. Taken together, our results highlight opportunities for the fabrication of self-reconfigurable host-guest protocells and provide a step towards the development of protocell populations exhibiting both synergistic and antagonistic modes of interaction. |
| 语种 | 英语 |
| WOS记录号 | WOS:000444014100027 |
| 出版者 | NATURE PUBLISHING GROUP |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/41899]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Mann, Stephen |
| 作者单位 | 1.Univ Bristol, Sch Chem, Ctr Protolife Res, Bristol BS8 1TS, Avon, England 2.Univ Bristol, Sch Chem, Ctr Organized Matter Chem, Bristol BS8 1TS, Avon, England 3.Univ Bordeaux, INRA, UMR Biol & Pathol Fruit 1332, Villenave Dornon, France 4.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Martin, Nicolas,Douliez, Jean-Paul,Qiao, Yan,et al. Antagonistic chemical coupling in self-reconfigurable host-guest protocells[J]. NATURE COMMUNICATIONS,2018,9. |
| APA | Martin, Nicolas,Douliez, Jean-Paul,Qiao, Yan,Booth, Richard,Li, Mei,&Mann, Stephen.(2018).Antagonistic chemical coupling in self-reconfigurable host-guest protocells.NATURE COMMUNICATIONS,9. |
| MLA | Martin, Nicolas,et al."Antagonistic chemical coupling in self-reconfigurable host-guest protocells".NATURE COMMUNICATIONS 9(2018). |
入库方式： OAI收割
来源：化学研究所
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