Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine
文献类型:期刊论文
作者 | He, Shasha1,2; Le, Chan5,6; Zhang, Qingfei1,2; Ding, Jianxun7; Liang, Xing-Jie5,6; Chen, Xuesi7; Xiao, Haihua2,4; Chen, Xiaoyuan1,3; Zhou, Dongfang1; Huang, Yubin1 |
刊名 | ACS NANO
![]() |
出版日期 | 2018-07-01 |
卷号 | 12期号:7页码:7272-7281 |
关键词 | Precise Nanomedicine Platinum Amphiphile Photoactivatable Targeting Imaging |
ISSN号 | 1936-0851 |
DOI | 10.1021/acsnano.8b03476 |
英文摘要 | Drug, targeting ligand, and imaging agent are the three essential components in a nanoparticle-based drug delivery system. However, tremendous batch-to-batch variation of composition and drug content typically accompany the current approaches of building these components together. Herein, we report the design of photoactivatable platinum(IV) (Pt(IV)) amphiphiles containing one or two hydrophilic lactose targeting ligands per hydrophobic Pt(IV) prodrug for an all-in one precise nanomedicine. Self-assembly of these Pt(IV) amphiphiles results in either micelle or vesicle formation with a fixed Pt/targeting moiety ratio and a constantly high content of Pt. The micelles and vesicles are capable of hepatoma cell targeting, fluorescence/Pt-based CT imaging and have shown effective anticancer efficacy under laser irradiation in vitro and in vivo. This photoactivatable, active self-targeting, and multimodal theranostic amphiphile strategy shows great potential in constructing precise nanomedicine. |
语种 | 英语 |
WOS记录号 | WOS:000440505000094 |
出版者 | AMER CHEMICAL SOC |
源URL | [http://ir.iccas.ac.cn/handle/121111/41907] ![]() |
专题 | 中国科学院化学研究所 |
通讯作者 | Xiao, Haihua; Chen, Xiaoyuan; Zhou, Dongfang |
作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.NIBIB, Lab Mol Imaging & Nanomed LOMIN, NIH, Bethesda, MD 20892 USA 4.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 5.Chinese Acad Sci, Ctr Excellence Nanosci, Beijing 100190, Peoples R China 6.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Lab Controllable Nanopharmaceut, Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Changchun Inst Appl Chem, Key Lab Polymer Ecomat, Changchun 130022, Jilin, Peoples R China |
推荐引用方式 GB/T 7714 | He, Shasha,Le, Chan,Zhang, Qingfei,et al. Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine[J]. ACS NANO,2018,12(7):7272-7281. |
APA | He, Shasha.,Le, Chan.,Zhang, Qingfei.,Ding, Jianxun.,Liang, Xing-Jie.,...&Huang, Yubin.(2018).Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine.ACS NANO,12(7),7272-7281. |
MLA | He, Shasha,et al."Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine".ACS NANO 12.7(2018):7272-7281. |
入库方式: OAI收割
来源:化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。