Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery
文献类型：期刊论文
| 作者 | Du, Libo1; Suo, Siqingaowa1; Luo, Dan2,3; Jia, Hongying1; Sha, Yinlin2,3; Liu, Yang1 |
| 刊名 | JOURNAL OF NANOPARTICLE RESEARCH
 |
| 出版日期 | 2013-06-01 |
| 卷号 | 15期号:6 |
| 关键词 | Graphene Methotrexate Drug Delivery Cytotoxicity Anticancer Drugs |
| ISSN号 | 1388-0764 |
| DOI | 10.1007/s11051-013-1708-0 |
| 英文摘要 | In this study, we presented a simple approach to prepare hydroxyethylated graphene oxide (HE-GO) with high water solubility and physiological stability. The successful synthesis of HE-GO was confirmed by UV-Vis spectroscopy, Fourier transform infrared spectroscopy, and atomic force microscopy. The loading of anticancer drug methotrexate (MTX) onto this nanocarrier (MTX/HE-GO) was investigated. The results of in vitro drug release experiment showed that the rate of MTX release from MTX/HE-GO was pH dependent. Moreover, cell viability assay demonstrated that HE-GO loaded with MTX exhibits higher anticancer activity against human lung adenocarcinoma epithelial cell line than non-vehicle MTX. |
| 语种 | 英语 |
| WOS记录号 | WOS:000319516400038 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42004]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Du, Libo |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Peking Univ, Sch Basic Med Sci, Dept Biophys, Single Mol & Nanobiol Lab, Beijing 100191, Peoples R China 3.Peking Univ, Biomed X Ctr, Beijing 100191, Peoples R China |
| 推荐引用方式 GB/T 7714 | Du, Libo,Suo, Siqingaowa,Luo, Dan,et al. Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery[J]. JOURNAL OF NANOPARTICLE RESEARCH,2013,15(6). |
| APA | Du, Libo,Suo, Siqingaowa,Luo, Dan,Jia, Hongying,Sha, Yinlin,&Liu, Yang.(2013).Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery.JOURNAL OF NANOPARTICLE RESEARCH,15(6). |
| MLA | Du, Libo,et al."Hydroxyethylated graphene oxide as potential carriers for methotrexate delivery".JOURNAL OF NANOPARTICLE RESEARCH 15.6(2013). |
入库方式： OAI收割
来源：化学研究所
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