Enhanced Photodynamic Efficiency of an Aptamer-Guided Fullerene Photosensitizer toward Tumor Cells
文献类型：期刊论文
| 作者 | Liu, Qiaoling; Xu, Li; Zhang, Xuejie; Li, Nan; Zheng, Junpeng; Guan, Mirong; Fang, Xiaohong; Wang, Chunru; Shu, Chunying |
| 刊名 | CHEMISTRY-AN ASIAN JOURNAL
 |
| 出版日期 | 2013-10-01 |
| 卷号 | 8期号:10页码:2370-2376 |
| 关键词 | Aptamers Cancer Fullerenes Nanoparticles Photodynamic Therapy |
| ISSN号 | 1861-4728 |
| DOI | 10.1002/asia.201300039 |
| 英文摘要 | Fullerene-based photosensitizers exhibit great potential in photodynamic therapy (PDT). Based on the high photodynamic efficacy of trimalonic acid-modified C-70 fullerene (TF70), we constructed an aptamer-guided TF70 photosensitizer and investigated its photodynamic effect. Conjugation of the novel aptamer (named R13) could effectively enhance the PDT efficiency of TF70 against A549 lung cancer cells in the presence of serum. The lysosomal location of the TF70-R13 conjugate inside cells facilitates the production of intracellular reactive oxygen species (ROS), which can efficiently kill cells, under light irradiation. The enhanced photodynamic efficiency, along with its good biocompatibility in the dark, makes TF70-R13 a highly promising photosensitizer for tumor-specific PDT. |
| 语种 | 英语 |
| WOS记录号 | WOS:000324748600013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42007]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Fang, Xiaohong |
| 作者单位 | Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Qiaoling,Xu, Li,Zhang, Xuejie,et al. Enhanced Photodynamic Efficiency of an Aptamer-Guided Fullerene Photosensitizer toward Tumor Cells[J]. CHEMISTRY-AN ASIAN JOURNAL,2013,8(10):2370-2376. |
| APA | Liu, Qiaoling.,Xu, Li.,Zhang, Xuejie.,Li, Nan.,Zheng, Junpeng.,...&Shu, Chunying.(2013).Enhanced Photodynamic Efficiency of an Aptamer-Guided Fullerene Photosensitizer toward Tumor Cells.CHEMISTRY-AN ASIAN JOURNAL,8(10),2370-2376. |
| MLA | Liu, Qiaoling,et al."Enhanced Photodynamic Efficiency of an Aptamer-Guided Fullerene Photosensitizer toward Tumor Cells".CHEMISTRY-AN ASIAN JOURNAL 8.10(2013):2370-2376. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。