FABRICATION OF POLY(BUTYLENE ADIPATE) NANOFIBEROUS MICROSPHERES
文献类型：期刊论文
| 作者 | Yi, Xiao-lin1; Yuan, Yin1; Shi, Xu-dong1; Jiang, Ni1; Gan, Zhi-hua1,2 |
| 刊名 | ACTA POLYMERICA SINICA
 |
| 出版日期 | 2013-06-20 |
| 期号 | 6页码:781-787 |
| 关键词 | Polymeric Microspheres Nanofibers Heterogeneous Nucleation Enzymatic Degradation |
| ISSN号 | 1000-3304 |
| DOI | 10.3724/SP.J.1105.2013.13043 |
| 英文摘要 | A new method was developed to fabricate polymeric microspheres which were composed of homogeneous nanofibers by means of the combination of heterogeneous nucleation and controlled hydrolysis. According to the role of heterogeneous nucleation of multimethyl-benzilidene sorbitol (TM6) and its influences on the crystalline morphology of poly(butylene adipate) (PBA),the PBA microspheres were first fabricated by means of single emulsion solvent evaporation (O/W) or double emulsion solvent evaporation (W/O/W), and then the influences of the nucleating agent TM6 on the morphological change of microspheres in the course of enzymatic degradation were studied. The results indicated that the PBA microspheres with porous structure were fabricated via the W/O/W method. The porous structure of microspheres is favorable for the diffusion of lipase buffer solution into the porous inner of microspheres, leading to the homogenous hydrolysis of PBA chains in microspheres, and finally resulting in the microspheres with nanofibrous structures. By means of W/O/W method, the PBA microspheres with homogeneous nanofibers in whole microspheres were fabricated when 3 wt% TM6 was added in PBA solution and the microspheres were degraded in lipase buffer solution for 5 h. The cell experiments revealed that the nanofibrous structure can greatly improve the adhesion, spread and in-growth of MG-63 cells on microspheres. These microspheres composed of nanofibers show great potentials for large-scaled cell proliferation in bioreactors. |
| 语种 | 英语 |
| WOS记录号 | WOS:000320297500008 |
| 出版者 | SCIENCE PRESS |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42018]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yi, Xiao-lin |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, CAS Key Lab Engn Plast, Beijing 100190, Peoples R China 2.Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Organ Inorgan Composites, Beijing 100029, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yi, Xiao-lin,Yuan, Yin,Shi, Xu-dong,et al. FABRICATION OF POLY(BUTYLENE ADIPATE) NANOFIBEROUS MICROSPHERES[J]. ACTA POLYMERICA SINICA,2013(6):781-787. |
| APA | Yi, Xiao-lin,Yuan, Yin,Shi, Xu-dong,Jiang, Ni,&Gan, Zhi-hua.(2013).FABRICATION OF POLY(BUTYLENE ADIPATE) NANOFIBEROUS MICROSPHERES.ACTA POLYMERICA SINICA(6),781-787. |
| MLA | Yi, Xiao-lin,et al."FABRICATION OF POLY(BUTYLENE ADIPATE) NANOFIBEROUS MICROSPHERES".ACTA POLYMERICA SINICA .6(2013):781-787. |
入库方式： OAI收割
来源：化学研究所
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