MDR1-targeted siRNA delivery with cationic dendritic conjugated polymers
文献类型：期刊论文
| 作者 | Feng XuLi; Lu FengTing; Liu LiBing; Wang Shu |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2013-08-01 |
| 卷号 | 58期号:22页码:2762-2766 |
| ISSN号 | 1001-6538 |
| 关键词 | Conjugated Polymers Sirna Delivery Multidrug Resistance Therapeutic |
| DOI | 10.1007/s11434-013-5899-7 |
| 英文摘要 | A cationic dendritic polyfluorene (PFP) is examined as a siRNA delivery vector. This material was designed to facilitate the nucleic acid binding, encapsulation and efficient cellular uptake. PFP can effectively protect siRNA against nuclease degradation, which is necessary for gene carriers. PFP can be used for multidrug resistance gene-targeted siRNA delivery in doxorubicin (Dox)-resistant human breast cancer cells (MCF7) cells. As a siRNA transfection agent, PFP can efficiently achieve the reversal of drug resistance and enhance the drug sensitivity. These new features and capabilities represent a major step toward conjugated polymers that can function for therapeutic application. |
| 语种 | 英语 |
| 出版者 | SCIENCE PRESS |
| WOS记录号 | WOS:000323342300014 |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42069]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu LiBing |
| 作者单位 | Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Feng XuLi,Lu FengTing,Liu LiBing,et al. MDR1-targeted siRNA delivery with cationic dendritic conjugated polymers[J]. CHINESE SCIENCE BULLETIN,2013,58(22):2762-2766. |
| APA | Feng XuLi,Lu FengTing,Liu LiBing,&Wang Shu.(2013).MDR1-targeted siRNA delivery with cationic dendritic conjugated polymers.CHINESE SCIENCE BULLETIN,58(22),2762-2766. |
| MLA | Feng XuLi,et al."MDR1-targeted siRNA delivery with cationic dendritic conjugated polymers".CHINESE SCIENCE BULLETIN 58.22(2013):2762-2766. |
入库方式： OAI收割
来源：化学研究所
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