Surface-Induced Hydrogelation Inhibits Platelet Aggregation
文献类型：期刊论文
| 作者 | Zheng, Wenting1,2; Gao, Jie1,2; Song, Lijie1,2; Chen, Chongyi3; Guan, Di1,2; Wang, Zhihong1,2; Li, Zhibo3; Kong, Deling1,2; Yang, Zhimou1,2 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2013-01-09 |
| 卷号 | 135期号:1页码:266-271 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/ja308690y |
| 英文摘要 | We demonstrate that a tripeptide hydrogelator, Nap-FFG, can selectively self-assemble at the surface of platelets, thus inhibiting ADP-, collagen-, thrombin- and arachidonic acid (AA)-induced human platelet aggregations with the IC50 values of 0.035 (41), 0.14 (162), 0.062 (68), and 0.13 mg/mL (148 mu M), respectively. Other tripeptide hydrogelators with chemical structures of Nap-FFX (X = A, K, S, or E) could not or possessed less potencies to inhibit platelet aggregations. We observed higher amounts of Nap-FFG at the platelet surface by the techniques of LC-MS and confocal microscopy. We also observed self-assembled nanofibers around the platelet incubated with the Nap-FFG by cryo-TEM. The C potential of Nap-FFG treated platelets was a little bit more negative than that of untreated ones. The amount of Nap-FFG at the surface of NIH 3T3 cells was much less than that of platelets. These observations suggested that Nap-FFG could selectively self-assemble through unknown ligand receptor interactions and form thin layers of hydrogels at the surface of platelets, thus preventing the aggregation of them. This study not only broadened the application and opened up a new door for biomedical applications of molecular hydrogels but also might provide a novel strategy to counteract infection diseases through selective surface-induced hydrogelations at pathogens, such as bacteria and virus. |
| 语种 | 英语 |
| WOS记录号 | WOS:000313143000045 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42144]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Zhibo |
| 作者单位 | 1.Nankai Univ, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R China 2.Nankai Univ, Coll Life Sci, Tianjin 300071, Peoples R China 3.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Wenting,Gao, Jie,Song, Lijie,et al. Surface-Induced Hydrogelation Inhibits Platelet Aggregation[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2013,135(1):266-271. |
| APA | Zheng, Wenting.,Gao, Jie.,Song, Lijie.,Chen, Chongyi.,Guan, Di.,...&Yang, Zhimou.(2013).Surface-Induced Hydrogelation Inhibits Platelet Aggregation.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,135(1),266-271. |
| MLA | Zheng, Wenting,et al."Surface-Induced Hydrogelation Inhibits Platelet Aggregation".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 135.1(2013):266-271. |
入库方式： OAI收割
来源：化学研究所
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