pH-Responsive Mechanism of a Deoxycholic Acid and Folate Comodified Chitosan Micelle under Cancerous Environment
文献类型：期刊论文
| 作者 | Chen, Daiqin1,2; Song, Peng3; Jiang, Feng1,2; Meng, Xiangyue1,2; Sui, Weiping3; Shu, Chunying1,2; Wan, Li-Jun1,2 |
| 刊名 | JOURNAL OF PHYSICAL CHEMISTRY B
 |
| 出版日期 | 2013-02-07 |
| 卷号 | 117期号:5页码:1261-1268 |
| ISSN号 | 1520-6106 |
| DOI | 10.1021/jp310677p |
| 英文摘要 | Smart pH-responsive polymeric micelles have attracted much attention as one of the most promising drug delivery candidates. In this paper, a different substitution of deoxycholic acid (DCA) and folic acid (FA) comodified hydroxypropyl chitosans (HPCHS) were synthesized for doxorubicin (DOX) targeted delivery and controllable release. The results indicate that the DOX-release behavior is pH-responsive and closely related with the grafting proportions of the two hydrophobic ingredients. The pH-responsive mechanism for the optimized (6%DCA)-HPCHS-(0.1%FA) was suggested, resulting from a synergistic effect of gradual hydrolysis of the amido bond and electrostatic repulsion between the subsequently protonated DOX and the amino residue of the chitosan backbone under a cancerous microenvironment. Moreover, the DOX/(6%DCA)-HPCHS-(0.1%FA) micelle as a promising targeted drug delivery system in cancer therapy was evaluated by cell growth inhibition assays and confocal laser microscopy in vitro. The results clearly demonstrate a controlled release of its cargo and promoted curative efficacy of DOX. |
| 语种 | 英语 |
| WOS记录号 | WOS:000314908100008 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42155]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Shu, Chunying |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing 100190, Peoples R China 2.Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 3.Univ Jinan, Sch Chem & Chem Engn, Jinan 250022, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Daiqin,Song, Peng,Jiang, Feng,et al. pH-Responsive Mechanism of a Deoxycholic Acid and Folate Comodified Chitosan Micelle under Cancerous Environment[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2013,117(5):1261-1268. |
| APA | Chen, Daiqin.,Song, Peng.,Jiang, Feng.,Meng, Xiangyue.,Sui, Weiping.,...&Wan, Li-Jun.(2013).pH-Responsive Mechanism of a Deoxycholic Acid and Folate Comodified Chitosan Micelle under Cancerous Environment.JOURNAL OF PHYSICAL CHEMISTRY B,117(5),1261-1268. |
| MLA | Chen, Daiqin,et al."pH-Responsive Mechanism of a Deoxycholic Acid and Folate Comodified Chitosan Micelle under Cancerous Environment".JOURNAL OF PHYSICAL CHEMISTRY B 117.5(2013):1261-1268. |
入库方式： OAI收割
来源：化学研究所
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