Effects of molecular weight on thermal responsive property of pegylated poly-l-glutamates
文献类型：期刊论文
| 作者 | Zhang, Shusheng; Chen, Chongyi; Li, Zhibo |
| 刊名 | CHINESE JOURNAL OF POLYMER SCIENCE
 |
| 出版日期 | 2013-02-01 |
| 卷号 | 31期号:2页码:201-210 |
| 关键词 | N-carboxyanhydride (Nca) Ring Opening Polymerization Polypeptide Helicity Thermal Responsive |
| ISSN号 | 0256-7679 |
| DOI | 10.1007/s10118-013-1218-7 |
| 英文摘要 | We investigated the ring opening polymerization (ROP) of di- and tri-ethylene glycol monomethyl ether functionalized L-glutamate N-carboxyanhydrides (NCAs) using hexamethyldisilazane (HMDS) as primary initiator and 1,5,7-triazabicyclo-[4.4.0]dec-5-ene (TBD) as co-initiator. The binary initiator system afforded a living ROP for these pegylated NCAs, and a series of homopolypeptides with controlled molecular weight (MW) and low polydispersity were obtained. We then systematically studied the helical content and clouding point (CP) dependence on polypeptide MW using circular dichroism (CD) spectroscopy and turbidity measurements, respectively. We found that the helical content of both homopolypeptides increased with MW, but the triethylene glycol functionalized poly-L-glutamate (poly-L-EG(3)Glu) intended to form more stable alpha-helical structure than diethylene glycol functionalized counterpart (poly-L-EG(2)Glu) at similar MW. Accordingly, the CP of poly-L-EG(2)Glu with known end group has strong dependence on its helical content, which is essentially determined by MW. Our results suggested that the thermal responsive properties of these unique pegylated poly-L-glutamates not only rely on their chemical structure but also on their secondary structures, which is different from conventional thermal responsive polymers. |
| 语种 | 英语 |
| WOS记录号 | WOS:000313054000001 |
| 出版者 | SPRINGER |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42205]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Zhibo |
| 作者单位 | Chinese Acad Sci, Inst Chem, Lab Polymer Phys & Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Shusheng,Chen, Chongyi,Li, Zhibo. Effects of molecular weight on thermal responsive property of pegylated poly-l-glutamates[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2013,31(2):201-210. |
| APA | Zhang, Shusheng,Chen, Chongyi,&Li, Zhibo.(2013).Effects of molecular weight on thermal responsive property of pegylated poly-l-glutamates.CHINESE JOURNAL OF POLYMER SCIENCE,31(2),201-210. |
| MLA | Zhang, Shusheng,et al."Effects of molecular weight on thermal responsive property of pegylated poly-l-glutamates".CHINESE JOURNAL OF POLYMER SCIENCE 31.2(2013):201-210. |
入库方式： OAI收割
来源：化学研究所
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