Carbon Nanodots As a Matrix for the Analysis of Low-Molecular-Weight Molecules in Both Positive- and Negative-Ion Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and Quantification of Glucose and Uric Acid in Real Samples
文献类型：期刊论文
| 作者 | Chen, Suming1; Zheng, Huzhi2; Wang, Jianing1; Hou, Jian1; He, Qing1; Liu, Huihui1; Xiong, Caiqiao1; Kong, Xianglei3; Nie, Zongxiu1,4 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2013-07-16 |
| 卷号 | 85期号:14页码:6646-6652 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/ac401601r |
| 英文摘要 | Carbon nanodots were applied for the first time as a new matrix for the analysis of low-molecular-weight compounds by matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) in both positive- and negative-ion modes. A wide range of small molecules including amino acids, peptides, fatty acids, as well as beta-agonists and neutral oligosaccharides were analyzed by MALDI MS with carbon nanodots as the matrix, and the lowest 0.2 fmol limits-of-detection were obtained for octadecanoic acid. Clear sodium and potassium adducts and deprotonated signals were produced in positive- and negative-ion modes. Furthermore, the glucose and uric acid in real samples were quantitatively determined by the internal standard method with the linear range of 0.5-9 mM and 0.1-1.8 mM (R-2 > 0.999), respectively. This work gives new insight into the application of carbon nanodots and provides a general approach for rapid analysis of low-molecular-weight compounds. |
| 语种 | 英语 |
| WOS记录号 | WOS:000322059600017 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42245]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Nie, Zongxiu |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Analyt Chem Living Biosyst, Inst Chem, Beijing 100190, Peoples R China 2.Southwest Univ, Key Lab Luminescence & Real Time Anal, Minist Educ, Coll Chem & Chem Engn, Chongqing 400715, Peoples R China 3.Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China 4.Beijing Ctr Mass Spectrometry, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Suming,Zheng, Huzhi,Wang, Jianing,et al. Carbon Nanodots As a Matrix for the Analysis of Low-Molecular-Weight Molecules in Both Positive- and Negative-Ion Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and Quantification of Glucose and Uric Acid in Real Samples[J]. ANALYTICAL CHEMISTRY,2013,85(14):6646-6652. |
| APA | Chen, Suming.,Zheng, Huzhi.,Wang, Jianing.,Hou, Jian.,He, Qing.,...&Nie, Zongxiu.(2013).Carbon Nanodots As a Matrix for the Analysis of Low-Molecular-Weight Molecules in Both Positive- and Negative-Ion Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and Quantification of Glucose and Uric Acid in Real Samples.ANALYTICAL CHEMISTRY,85(14),6646-6652. |
| MLA | Chen, Suming,et al."Carbon Nanodots As a Matrix for the Analysis of Low-Molecular-Weight Molecules in Both Positive- and Negative-Ion Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry and Quantification of Glucose and Uric Acid in Real Samples".ANALYTICAL CHEMISTRY 85.14(2013):6646-6652. |
入库方式： OAI收割
来源：化学研究所
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