Intrauterine Inflammation Increases Materno-Fetal Transfer of Gold Nanoparticles in a Size-Dependent Manner in Murine Pregnancy
文献类型：期刊论文
| 作者 | Tian, Xin1,2; Zhu, Motao1; Du, Libo4; Wang, Jing1; Fan, Zhenlin1,5; Liu, Jun1; Zhao, Yuliang1,3; Nie, Guangjun1 |
| 刊名 | SMALL
 |
| 出版日期 | 2013-07-22 |
| 卷号 | 9期号:14页码:2432-2439 |
| 关键词 | Gold Nanoparticles Pregnancy Materno-fetal Transfer Intrauterine Inflammation Nanosafety |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201300817 |
| 英文摘要 | The materno-fetal transfer of nanoparticles is a critical issue in designing theranoustic nanoparticles for in vivo applications during pregnancy. Recent studies have reported that certain nanoparticles can cross the placental barrier in healthy pregnant animals depending on the size and surface modification of the nanoparticles and the developmental stages of the fetuses. However, materno-fetal transfer under pathological pregnant conditions has not been examined so far. Here, it is shown that intrauterine inflammation can enhance the materno-fetal transfer of nanoparticles in the late gestation stage of murine pregnancy in a size-dependent manner. Three different-sized gold nanoparticles (Au NPs) with diameters of 3 (Au3), 13 (Au13) and 32 (Au32) nm are applied. The accumulation of Au3 and Au13 nanoparticles in the fetuses is significantly increased in intrauterine inflammatory mice compared with healthy control mice: the concentration of Au3 is much higher than Au13 in fetal tissues of intrauterine inflammatory mice. In contrast, Au32 nanoparticles cannot cross the placental barrier either in healthy or in intrauterine inflammatory mice. The possible underlying mechanism of the increased materno-fetal transfer of small-sized nanoparticles on pathological conditions is inferred to be the structural and functional abnormalities of the placenta under intrauterine inflammation. The size of the nanoparticles is one of the critical factors which determines the extent of fetal exposure to nanoparticles in murine pregnancy under inflammatory conditions. |
| 语种 | 英语 |
| WOS记录号 | WOS:000327697500013 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42255]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Nie, Guangjun |
| 作者单位 | 1.Chinese Acad Sci, Key Lab Biomed Effects Nanomat & Nanosafety, Natl Ctr Nanosci & Technol China, Beijing 100190, Peoples R China 2.Soochow Univ, Sch Radiol & Interdisciplinary Sci, Suzhou 215123, Jiangsu, Peoples R China 3.Chinese Acad Sci, Inst High Energy Phys, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 5.Jilin Univ, Coll Pharmaceut Sci, Changchun 130021, Peoples R China |
| 推荐引用方式 GB/T 7714 | Tian, Xin,Zhu, Motao,Du, Libo,et al. Intrauterine Inflammation Increases Materno-Fetal Transfer of Gold Nanoparticles in a Size-Dependent Manner in Murine Pregnancy[J]. SMALL,2013,9(14):2432-2439. |
| APA | Tian, Xin.,Zhu, Motao.,Du, Libo.,Wang, Jing.,Fan, Zhenlin.,...&Nie, Guangjun.(2013).Intrauterine Inflammation Increases Materno-Fetal Transfer of Gold Nanoparticles in a Size-Dependent Manner in Murine Pregnancy.SMALL,9(14),2432-2439. |
| MLA | Tian, Xin,et al."Intrauterine Inflammation Increases Materno-Fetal Transfer of Gold Nanoparticles in a Size-Dependent Manner in Murine Pregnancy".SMALL 9.14(2013):2432-2439. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。