Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway
文献类型：期刊论文
| 作者 | Zhou, Lihua1; Wu, Yayun1,2; Meng, Xiaoqing1; Li, Sanpeng1; Zhang, Jiali1; Gong, Ping1,3; Zhang, Pengfei1; Jiang, Tao1; Deng, Guanjun1; Li, Wenjun1 |
| 刊名 | SMALL
 |
| 出版日期 | 2018-09-06 |
| 卷号 | 14期号:36 |
| 关键词 | Dye-anchored Mno Nanoparticles Phototherapy Reactive Oxide Species Tumor Microenvironment Tumor Mitochondria Targeting |
| ISSN号 | 1613-6810 |
| DOI | 10.1002/smll.201801008 |
| 英文摘要 | Phototherapy is a promising treatment method for cancer therapy. However, the various factors have greatly restricted phototherapy development, including the poor accumulation of photosensitizer in tumor, hypoxia in solid tumor tissue and systemic phototoxicity. Herein, a mitochondrial-targeted multifunctional dye-anchored manganese oxide nanoparticle (IR808@MnO NP) is developed for enhancing phototherapy of cancer. In this nanoplatform, IR808 as a small molecule dye acts as a tumor targeting ligand to make IR808@MnO NPs with capacity to actively target tumor cells and relocate finally in the mitochondria. Meanwhile, continuous production of oxygen (O-2) and regulation of pH induced by the high reactivity and specificity of MnO NPs toward mitochondrial endogenous hydrogen peroxide (H2O2) could effectively modulate tumor hypoxia and lessen the tumor subacid environment. Large amounts of reactive oxide species (ROS) are generated during the reaction process between H2O2 and MnO NPs. Furthermore, under laser irradiation, IR808 in IR808@MnO NPs turns O-2 into a highly toxic singlet oxygen (O-1(2)) and generates hyperthermia. The results indicate that IR808@MnO NPs have the high efficiency of specific targeting of tumors, relieving tumor subacid environment, improving the tumor hypoxia environment, and generating large amounts of ROS to kill tumor cells. It is expected to have a wide application in treating cancer. |
| 语种 | 英语 |
| WOS记录号 | WOS:000443812600005 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42313]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Gong, Ping; Cai, Lintao |
| 作者单位 | 1.Chinese Acad Sci, SIAT,Inst Biomed & Biotechnol,Guangdong Key Lab N, Shenzhen Engn Lab Nanomed & Nanoformulat, CAS HK Joint Lab Biomat,CAS Key Lab Hlth Informat, Shenzhen 518055, Peoples R China 2.Chinese Acad Sci, CAS Res Educ Ctr Excellence Mol Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing 100190, Peoples R China 3.Guangdong Med Univ, Key Lab Nanomed, Dongguan Key Lab Drug Design & Formulat Technol, Dongguan 523808, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lihua,Wu, Yayun,Meng, Xiaoqing,et al. Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway[J]. SMALL,2018,14(36). |
| APA | Zhou, Lihua.,Wu, Yayun.,Meng, Xiaoqing.,Li, Sanpeng.,Zhang, Jiali.,...&Cai, Lintao.(2018).Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway.SMALL,14(36). |
| MLA | Zhou, Lihua,et al."Dye-Anchored MnO Nanoparticles Targeting Tumor and Inducing Enhanced Phototherapy Effect via Mitochondria-Mediated Pathway".SMALL 14.36(2018). |
入库方式： OAI收割
来源：化学研究所
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