Bioinspired Peptide for Imaging Hg2+ Distribution in Living Cells and Zebrafish Based on Coordination-Mediated Supramolecular Assembling
文献类型：期刊论文
| 作者 | Gui, Shilang1,2; Huang, Yanyan1,2; Hu, Fang1,2; Jin, Yulong1,2; Zhang, Guanxin1,2; Zhang, Deqing1,2; Zhao, Rui1,2 |
| 刊名 | ANALYTICAL CHEMISTRY
 |
| 出版日期 | 2018-08-21 |
| 卷号 | 90期号:16页码:9708-9715 |
| ISSN号 | 0003-2700 |
| DOI | 10.1021/acs.analchem.8b00059 |
| 英文摘要 | Peptides with modular structure provide a tailorable platform for constructing responsive supramolecular assemblies, which are attractive as functional biomaterials and smart sensors. In this work, the feasibility of regulating small peptides assembly with molecular design and metal ion recognition was demonstrated. Tripeptides were designed and found to have diverse response and self-assembly behavior to Hg2+. The incorporation of an aggregation-induced emission fluorophore TPE enabled the visualization of Hg2+ recognition and the assembly phenomenon. A structural analogue (Pep2) to gamma-glutathione was identified with high specificity and nanomolar response to Hg2+ both in buffer solution and living cells. Driven by the coordination force and noncovalent intramolecular stacking, assembling of twisted nanofibers from Pep2-TPE and Hg2+ were observed. Benefiting from its biocompatibility, fast and switchable fluorescence response, Pep2-TPE was applied for imaging and monitoring Hg2+ distribution in living cells and zebrafish. With good permeability to plasma membrane and tissues, Pep2-TPE indicated the preferential distribution of Hg2+ in cell nucleoli and brain of zebrafish, which is related with the deleterious effect of inorganic mercury in living biosystems. |
| 语种 | 英语 |
| WOS记录号 | WOS:000442707100011 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42355]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Huang, Yanyan; Zhao, Rui |
| 作者单位 | 1.Chinese Acad Sci, Beijing Natl Res Ctr Mol Sci, CAS Key Labs Analyt Chem Living Biosyst & Organ S, Inst Chem,CAS Res Educ Ctr Excellence Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Gui, Shilang,Huang, Yanyan,Hu, Fang,et al. Bioinspired Peptide for Imaging Hg2+ Distribution in Living Cells and Zebrafish Based on Coordination-Mediated Supramolecular Assembling[J]. ANALYTICAL CHEMISTRY,2018,90(16):9708-9715. |
| APA | Gui, Shilang.,Huang, Yanyan.,Hu, Fang.,Jin, Yulong.,Zhang, Guanxin.,...&Zhao, Rui.(2018).Bioinspired Peptide for Imaging Hg2+ Distribution in Living Cells and Zebrafish Based on Coordination-Mediated Supramolecular Assembling.ANALYTICAL CHEMISTRY,90(16),9708-9715. |
| MLA | Gui, Shilang,et al."Bioinspired Peptide for Imaging Hg2+ Distribution in Living Cells and Zebrafish Based on Coordination-Mediated Supramolecular Assembling".ANALYTICAL CHEMISTRY 90.16(2018):9708-9715. |
入库方式： OAI收割
来源：化学研究所
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