Target discovery of ebselen with a biotinylated probe
文献类型：期刊论文
| 作者 | Chen, Zhenzhen1; Jiang, Zhongyao1; Chen, Nan2; Shi, Qian1; Tong, Lili1; Kong, Fanpeng1; Cheng, Xiufen1; Chen, Hao3; Wang, Chu2; Tang, Bo1 |
| 刊名 | CHEMICAL COMMUNICATIONS
 |
| 出版日期 | 2018-09-04 |
| 卷号 | 54期号:68页码:9506-9509 |
| ISSN号 | 1359-7345 |
| DOI | 10.1039/c8cc04258f |
| 英文摘要 | Despite numerous studies on ebselen over the past decade, its cellular targets remain obscure. Here we synthesized a biotinylated ebselen probe (biotin-ebselen) and characterized ebselen-binding proteins via an efficient activity-based protein profiling (ABPP) method, which allowed for the robust identification of 462 targeted proteins in HeLa cells. This first work of global target profiling of ebselen will be helpful to re-design ebselen-based therapy appropriately in clinical trials. |
| 语种 | 英语 |
| WOS记录号 | WOS:000442385200030 |
| 出版者 | ROYAL SOC CHEMISTRY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42379]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Chu; Tang, Bo |
| 作者单位 | 1.Univ Shandong, Collaborat Innovat Ctr Functionalized Probes Chem, Coll Chem Chem Engn & Mat Sci, Key Lab Mol & Nano Probes,Minist Educ, Jinan 250014, Shandong, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Key Lab Bioorgan Chem & Mol Engn,Minist Educ, Beijing 100871, Peoples R China 3.Ohio Univ, Dept Chem & Biochem, Athens, OH 45701 USA |
| 推荐引用方式 GB/T 7714 | Chen, Zhenzhen,Jiang, Zhongyao,Chen, Nan,et al. Target discovery of ebselen with a biotinylated probe[J]. CHEMICAL COMMUNICATIONS,2018,54(68):9506-9509. |
| APA | Chen, Zhenzhen.,Jiang, Zhongyao.,Chen, Nan.,Shi, Qian.,Tong, Lili.,...&Tang, Bo.(2018).Target discovery of ebselen with a biotinylated probe.CHEMICAL COMMUNICATIONS,54(68),9506-9509. |
| MLA | Chen, Zhenzhen,et al."Target discovery of ebselen with a biotinylated probe".CHEMICAL COMMUNICATIONS 54.68(2018):9506-9509. |
入库方式： OAI收割
来源：化学研究所
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