Nanopurpurin-based photodynamic therapy destructs extracellular matrix against intractable tumor metastasis
文献类型：期刊论文
| 作者 | Zhang, Di1,2; Feng, Feng1,2; Li, Qilong1,2; Wang, Xiuyu1,2; Yao, Li1,2 |
| 刊名 | BIOMATERIALS
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 173页码:22-33 |
| 关键词 | Adhesion Extracellular Matrix Biomechanical Forces Photodynamic Therapy Tumor Metastasis |
| ISSN号 | 0142-9612 |
| DOI | 10.1016/j.biomaterials.2018.04.045 |
| 英文摘要 | Nanomaterials-based photodynamic therapy (PDT) has been used to treat malignant cells. However, the intrinsic impact of nanomaterials-based PDT on mechanical properties of intractable tumor cells is not well understood. Herein, we demonstrated that the mechanical forces of Taxol-resistant tumor cells were decreased by nanopurpurin-based PDT destructing extracellular matrix (ECM), increasing therapy sensitivity and repressing tumor metastasis. Combining FIRMS and general confocal microscope, we observed that the disruption of ECM by photodynamic reaction of P18-nanoconfined liposome (P18 subset of L) induced a decrease of adhesion force and biomechanical properties of Taxol-resistant cells through the attenuation of actomyosin-based contractility thereby inhibiting cell migration and metastasis in vivo. Moreover, the destroyed ECM by P18 subset of L PDT increased the therapy sensitivity. A clearer understanding of the effect of nanopurpurin-based PDT on mechanical properties and behaviors of intractable tumor cells will provide new and important basis for developing new therapeutic strategies. (C) 2018 Elsevier Ltd. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000436054300003 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42493]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yao, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhang, Di,Feng, Feng,Li, Qilong,et al. Nanopurpurin-based photodynamic therapy destructs extracellular matrix against intractable tumor metastasis[J]. BIOMATERIALS,2018,173:22-33. |
| APA | Zhang, Di,Feng, Feng,Li, Qilong,Wang, Xiuyu,&Yao, Li.(2018).Nanopurpurin-based photodynamic therapy destructs extracellular matrix against intractable tumor metastasis.BIOMATERIALS,173,22-33. |
| MLA | Zhang, Di,et al."Nanopurpurin-based photodynamic therapy destructs extracellular matrix against intractable tumor metastasis".BIOMATERIALS 173(2018):22-33. |
入库方式： OAI收割
来源：化学研究所
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