Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy
文献类型：期刊论文
| 作者 | Cao, Hongqian1,2; Yang, Yang2; Qi, Yanfei1; Li, Yue2; Sun, Bingbing3; Li, Ying2; Cui, Wei3; Li, Juan1; Li, Junbai3 |
| 刊名 | ADVANCED HEALTHCARE MATERIALS
 |
| 出版日期 | 2018-06-20 |
| 卷号 | 7期号:12 |
| 关键词 | Immobilized Enzymes Intraparticle Fret Photodynamic Therapies Two-photon Excitation Vaterite Nanoparticles |
| ISSN号 | 2192-2640 |
| DOI | 10.1002/adhm.201701357 |
| 英文摘要 | Photodynamic therapy (PDT) still faces two main problems on cancer therapy. One is how to improve PDT efficiency against hypoxic environment of tumors. The other one is how to overcome the limit of short wavelength light to increase PDT treatment depth. In this work, an intraparticle fluorescence resonance energy transfer (FRET) platform is designed to address these problems together. The nanoparticles are doped with multicomponents, such as catalase, two-photon dyes, and traditional photosensitizers, with a simple "one-pot" and green method. On the one hand, catalase can catalyze intracellular H2O2 into O-2 and promote PDT efficiency. One the other hand, photosensitizers can be excited indirectly by two-photon lasers through an intraparticle FRET mechanism, which results in deeper tissue penetration for PDT. These properties are verified through the material induced cytotoxicity in light or in dark and in vivo blocking blood-vessel experiment. |
| 语种 | 英语 |
| WOS记录号 | WOS:000435764200003 |
| 出版者 | WILEY |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42533]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Yang, Yang; Li, Juan; Li, Junbai |
| 作者单位 | 1.Jilin Univ, Sch Publ Hlth, Changchun 130021, Jilin, Peoples R China 2.Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, Beijing 100190, Peoples R China 3.Chinese Acad Sci, CAS Key Lab Colloid Interface & Chem Thermodynam, Inst Chem, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Cao, Hongqian,Yang, Yang,Qi, Yanfei,et al. Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy[J]. ADVANCED HEALTHCARE MATERIALS,2018,7(12). |
| APA | Cao, Hongqian.,Yang, Yang.,Qi, Yanfei.,Li, Yue.,Sun, Bingbing.,...&Li, Junbai.(2018).Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy.ADVANCED HEALTHCARE MATERIALS,7(12). |
| MLA | Cao, Hongqian,et al."Intraparticle FRET for Enhanced Efficiency of Two-Photon Activated Photodynamic Therapy".ADVANCED HEALTHCARE MATERIALS 7.12(2018). |
入库方式： OAI收割
来源：化学研究所
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