Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy
文献类型：期刊论文
| 作者 | Yuan, Yue1; Zhang, Qin1; Yan, Yun2; Gong, Miaomiao1; Zhao, Qi1; Bao, Zhihong1; Liu, Kaerdun2; Wang, Siling1 |
| 刊名 | DRUG DELIVERY
 |
| 出版日期 | 2018 |
| 卷号 | 25期号:1页码:623-631 |
| 关键词 | Self-assembly Vesicles Dox Encapsulation Efficiency Cellular Uptake |
| ISSN号 | 1071-7544 |
| DOI | 10.1080/10717544.2018.1440448 |
| 英文摘要 | We report a simple strategy to prepare Tween 60@2 beta-CD self-assembly vesicles in aqueous solution as a new drug delivery carrier for cancer chemotherapy. The spherical shape of vesicles was confirmed by transmission electron microscopy (TEM) and mean particle sizes were about 33.7 nm, as measured by dynamic light scattering, micro-IR results indicated that the self-assembly vesicles was driven by hydrogen bonding. Hydrophilic doxorubicin (DOX) was successfully loaded into the self-assembly vesicles with drug loading content of 7.85% and loading efficiency of 42%. In addition, an in vitro cytotoxicity study and cellular uptake assays demonstrated that the DOX-loaded Tween 60@2 beta-CD vesicles markedly enhanced the cellular uptake and cytotoxicity of DOX toward the Hela cells. Furthermore, when used to evaluate the in vivo therapeutic efficacy in mice bearing the breast cell line (4T1), DOX-loaded vesicles exhibited superior inhibition of tumor growth compared with the DOX solutions. |
| 语种 | 英语 |
| WOS记录号 | WOS:000436211000001 |
| 出版者 | TAYLOR & FRANCIS LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42541]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Wang, Siling |
| 作者单位 | 1.Shenyang Pharmaceut Univ, Sch Pharm, 103 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China 2.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Yue,Zhang, Qin,Yan, Yun,et al. Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy[J]. DRUG DELIVERY,2018,25(1):623-631. |
| APA | Yuan, Yue.,Zhang, Qin.,Yan, Yun.,Gong, Miaomiao.,Zhao, Qi.,...&Wang, Siling.(2018).Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy.DRUG DELIVERY,25(1),623-631. |
| MLA | Yuan, Yue,et al."Designed construction of tween 60@2 beta-CD self-assembly vesicles as drug delivery carrier for cancer chemotherapy".DRUG DELIVERY 25.1(2018):623-631. |
入库方式： OAI收割
来源：化学研究所
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