Nanoparticles of Chlorin Dimer with Enhanced Absorbance for Photoacoustic Imaging and Phototherapy
文献类型：期刊论文
| 作者 | Zheng, Xiaohua1,2; Wang, Lei1; Liu, Shi1; Zhang, Wei1,3; Liu, Feng1,2; Xie, Zhigang1 |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2018-06-27 |
| 卷号 | 28期号:26 |
| 关键词 | Cancer Therapy Chlorin Photoacoustic Imaging Photodynamic Therapy Photothermal Therapy Porphyrin |
| ISSN号 | 1616-301X |
| DOI | 10.1002/adfm.201706507 |
| 英文摘要 | Nanoparticle assembled from organic molecules is a versatile platform to integrate various functionalities for theranostics. In this work, nanoparticles are constructed from chlorin dimers that are synthesized by reducing porphyrin molecules. Chlorin dimers can assemble into nanoscale aggregates in the absence of surfactants or other auxiliary agent. The resulting nanoparticles of chlorin dimer exhibit much higher absorbance than the porphyrin counterparts, resulting in enhanced photodynamic and photothermal activity upon irradiation. The forming nanoparticles can be effectively endocytosed by the tumor cells, inducing apoptosis under irradiation. Tumor growth on mice model is inhibited by the photodynamic and photothermal treatment in vivo. Furthermore, this nanoparticle can be used for photoacoustic imaging. It is believed that the integrated imaging and phototherapeutic capability in one nanoparticle is beneficial for future cancer diagnosis, therapy, and molecular imaging. |
| 语种 | 英语 |
| WOS记录号 | WOS:000436104800022 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42555]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Xie, Zhigang |
| 作者单位 | 1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 2.Univ Sci & Technol China, Hefei 230026, Anhui, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Xiaohua,Wang, Lei,Liu, Shi,et al. Nanoparticles of Chlorin Dimer with Enhanced Absorbance for Photoacoustic Imaging and Phototherapy[J]. ADVANCED FUNCTIONAL MATERIALS,2018,28(26). |
| APA | Zheng, Xiaohua,Wang, Lei,Liu, Shi,Zhang, Wei,Liu, Feng,&Xie, Zhigang.(2018).Nanoparticles of Chlorin Dimer with Enhanced Absorbance for Photoacoustic Imaging and Phototherapy.ADVANCED FUNCTIONAL MATERIALS,28(26). |
| MLA | Zheng, Xiaohua,et al."Nanoparticles of Chlorin Dimer with Enhanced Absorbance for Photoacoustic Imaging and Phototherapy".ADVANCED FUNCTIONAL MATERIALS 28.26(2018). |
入库方式： OAI收割
来源：化学研究所
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