Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides
文献类型：期刊论文
| 作者 | Nie, Yanzhao1; Zhi, Xinmei1; Du, Haifeng2; Yang, Jing1 |
| 刊名 | MOLECULES
 |
| 出版日期 | 2018-04-01 |
| 卷号 | 23期号:4 |
| 关键词 | Lewis Pair Polymerization Polymerization Catalysis Polymer Synthesis Polypeptides Ring-opening Polymerization |
| ISSN号 | 1420-3049 |
| DOI | 10.3390/molecules23040760 |
| 英文摘要 | Despite notable progress, the fabrication of well-defined polypeptides via controlled ring-opening polymerization (ROP) of alpha-amino acid N-carboxyanhydrides (NCAs) using convenient catalysts under mild conditions in a relatively short polymerization time is still challenging. Herein, an easily obtained catalyst system composed of zinc acetate and aniline was explored to mediate the fast ROP of gamma-benzyl-L-glutamate-N-carboxyanhydride (BLG-NCA) monomer, to produce poly(gamma-benzyl-L-glutamates) (PBLGs) with controllable molecular weights and narrow dispersity. Considering the excellent cooperative action of zinc acetate and a broad scope of aniline derivatives with different functional groups to control ROP of BLG-NCA, this method may offer a useful platform enabling the rapid generation of end-functionalized PBLG and block copolymers for numerous biomedical applications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000434717300052 |
| 出版者 | MDPI |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42587]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Du, Haifeng; Yang, Jing |
| 作者单位 | 1.Beijing Univ Chem Technol, Coll Life Sci & Technol, State Key Lab Chem Resource Engn, Beijing Key Lab Bioproc, Beijing 100029, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, CAS Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Nie, Yanzhao,Zhi, Xinmei,Du, Haifeng,et al. Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides[J]. MOLECULES,2018,23(4). |
| APA | Nie, Yanzhao,Zhi, Xinmei,Du, Haifeng,&Yang, Jing.(2018).Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides.MOLECULES,23(4). |
| MLA | Nie, Yanzhao,et al."Zn(OAc)(2)-Catalyzing Ring-Opening Polymerization of N-Carboxyanhydrides for the Synthesis of Well-Defined Polypeptides".MOLECULES 23.4(2018). |
入库方式： OAI收割
来源：化学研究所
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