Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy
文献类型：期刊论文
| 作者 | Li, Meng; He, Ping; Li, Shengliang; Wang, Xiaoyu; Liu, Libing; Lv, Fengting; Wang, Shu |
| 刊名 | ACS BIOMATERIALS SCIENCE & ENGINEERING
 |
| 出版日期 | 2018-06-01 |
| 卷号 | 4期号:6页码:2037-2045 |
| 关键词 | Conjugated Oligomer Responsive Hydrogel Cell Imaging Photodynamic Therapy |
| ISSN号 | 2373-9878 |
| DOI | 10.1021/acsbiomaterials.7b00610 |
| 英文摘要 | Tumor-cell targeted and subcellular organelles-specific photo-sensitizer is imperative for high-efficiency photodynamic therapy (PDT). Herein, we designed and synthesized a new conjugated oligomer, oligo(p-phenylenevinylene-co-benzothiazole) (OPVBT), which could be used as photosensitizer to generate reactive oxygen species (ROS) upon light illumination. Advantageously, OPVBT was found to specifically accumulate in mitochondria, which is beneficial for effective subcellular organelles-targeted PDT. A biocompatible and biodegradable hydrogel was constructed based on Michael-type addition between cysteine-terminated matrix metalloproteinase (MMP)-cleavable oligopeptides and 4-arm vinyl sulfone-terminated poly-(ethylene glycol) (PEG-VS). By functionalizing hydrogel with OPVBT and cell adhesion peptide motif RGD, cell attachment and spreading on the hydrogel were easily realized. More importantly, because of the MMP-sensitivity of the hydrogel, tumor cells could be specifically lighted up by OPVBT liberated from the hydrogel and the growth of tumor cells are further restrained by ROS generated from OPVBT upon light illumination. The hybrid hydrogel provides a new platform for tumor-specific imaging and killing, which shows good potential for constructing targeted PDT system with reduced side effects. |
| 语种 | 英语 |
| WOS记录号 | WOS:000435226300013 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42635]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Libing; Wang, Shu |
| 作者单位 | Chinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Meng,He, Ping,Li, Shengliang,et al. Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy[J]. ACS BIOMATERIALS SCIENCE & ENGINEERING,2018,4(6):2037-2045. |
| APA | Li, Meng.,He, Ping.,Li, Shengliang.,Wang, Xiaoyu.,Liu, Libing.,...&Wang, Shu.(2018).Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy.ACS BIOMATERIALS SCIENCE & ENGINEERING,4(6),2037-2045. |
| MLA | Li, Meng,et al."Oligo(p-phenylenevinylene) Derivative-Incorporated and Enzyme-Responsive Hybrid Hydrogel for Tumor Cell-Specific Imaging and Activatable Photodynamic Therapy".ACS BIOMATERIALS SCIENCE & ENGINEERING 4.6(2018):2037-2045. |
入库方式： OAI收割
来源：化学研究所
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