Supramolecularly Engineered Circular Bivalent Aptamer for Enhanced Functional Protein Delivery
文献类型：期刊论文
| 作者 | Jiang, Ying1,4,5,6; Pan, Xiaoshu4,5,6; Chang, Jin7,8; Niu, Weijia4,5,6; Hou, Weijia4,5,6; Kuai, Hailan1; Zhao, Zilong1; Liu, Ji7,8; Wang, Ming7,8; Tan, Weihong1,2,3,4,5,6 |
| 刊名 | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
 |
| 出版日期 | 2018-06-06 |
| 卷号 | 140期号:22页码:6780-6784 |
| ISSN号 | 0002-7863 |
| DOI | 10.1021/jacs.8b03442 |
| 英文摘要 | Circular bivalent aptamers (cb-apt) comprise an emerging class of chemically engineered aptamers with substantially improved stability and molecular recognition ability. Its therapeutic application, however, is challenged by the lack of functional modules to control the interactions of cb-apt with therapeutics. We present the design of a beta-cyclodextrin-modified cb-apt (cb-apt-beta CD) and its supramolecular interaction with molecular therapeutics via host guest chemistry for targeted intracellular delivery. The supramolecular ensemble exhibits high serum stability and enhanced intracellular delivery efficiency compared to a monomeric aptamer. The cb-apt-beta CD ensemble delivers green fluorescent protein into targeted cells with efficiency as high as 80%, or cytotoxic saporin to efficiently inhibit tumor cell growth. The strategy of conjugating beta CD to cb-apt, and subsequently modulating the supramolecular chemistry of cb-apt-beta CD, provides a general platform to expand and diversify the function of aptamers, enabling new biological and therapeutic applications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000434895200011 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42651]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Zhao, Zilong; Wang, Ming; Tan, Weihong |
| 作者单位 | 1.Hunan Univ, Mol Sci & Biomed Lab, State Key Lab Chemo Biosensing & Chemometr, Coll Chem & Chem Engn,Coll Life Sci,Aptamer Engn, Changsha 410082, Hunan, Peoples R China 2.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Inst Mol Med, Shanghai 200240, Peoples R China 3.Shanghai Jiao Tong Univ, Coll Chem & Chem Engn, Shanghai 200240, Peoples R China 4.Univ Florida, Dept Chem, Ctr Res Bio Nano Interface, Gainesville, FL 32611 USA 5.Univ Florida, Dept Physiol & Funct Genom, Shands Canc Ctr, UF Genet Inst, Gainesville, FL 32611 USA 6.Univ Florida, McKnight Brain Inst, Gainesville, FL 32611 USA 7.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China 8.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Jiang, Ying,Pan, Xiaoshu,Chang, Jin,et al. Supramolecularly Engineered Circular Bivalent Aptamer for Enhanced Functional Protein Delivery[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2018,140(22):6780-6784. |
| APA | Jiang, Ying.,Pan, Xiaoshu.,Chang, Jin.,Niu, Weijia.,Hou, Weijia.,...&Tan, Weihong.(2018).Supramolecularly Engineered Circular Bivalent Aptamer for Enhanced Functional Protein Delivery.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,140(22),6780-6784. |
| MLA | Jiang, Ying,et al."Supramolecularly Engineered Circular Bivalent Aptamer for Enhanced Functional Protein Delivery".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 140.22(2018):6780-6784. |
入库方式： OAI收割
来源：化学研究所
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