Fluorescence turn-on assay for detection of serum D-penicillamine based on papain@AuNCs-Cu2+ complex
文献类型：期刊论文
| 作者 | Chen, Yifan1,3; Qiao, Juan1,2; Liu, Qianrong1,4; Zhang, Mingming1,5; Qi, Li1,2 |
| 刊名 | ANALYTICA CHIMICA ACTA
 |
| 出版日期 | 2018-10-05 |
| 卷号 | 1026页码:133-139 |
| 关键词 | Papain@auncs Fluorescence Turn On D-penicillamine Metabolic Process |
| ISSN号 | 0003-2670 |
| DOI | 10.1016/j.aca.2018.04.014 |
| 英文摘要 | Papain-stabilized gold nanoclusters (papain@AuNCs) with a red fluorescence emission at 639 nm have been generated successfully in aqueous solution. The fluorescence of papain@AuNCs could be quenched in the addition of Cu2+. Subsequently, a unique fluorescent probe based on papain@AuNCs-Cu2+ complex has been constructed for sensitive, selective and "turn-on" detection of D-penicillamine (D-pen). The sensing probe has exhibited a remarkable fluorescence enhancement in the presence of D-pen, which can be measured ranging from 30.0 mu M to 2.0 mM (r(2) = 0.991) with the detection limit of 5.0 mu M. Furthermore, the developed assay has been utilized to explore the metabolic process of D-pen in rats after intraperitoneal injection. As far as we concerned, the present study has reported the first analytical method for sensing serum D-pen in real time by using the fluorescent papain@AuNCs-Cu2+ complex. Our strategy paves a way for digging up the biological and clinical application of the fluorescent AuNCs. (C) 2018 Elsevier B.V. All rights reserved. |
| 语种 | 英语 |
| WOS记录号 | WOS:000433246100013 |
| 出版者 | ELSEVIER SCIENCE BV |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42753]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Qi, Li |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Key Lab Analyt Chem Living Biosyst, Beijing Natl Lab Mol Sci, 2 Zhongguancun Beiyijie, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19A Yuquanlu, Beijing 100049, Peoples R China 3.Jilin Univ, Zhuhai Coll, Zhuhai 519041, Peoples R China 4.Xian Univ Sci & Technol, Xian 710054, Shaanxi, Peoples R China 5.Tianjin Normal Univ, Tianjin 300387, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Yifan,Qiao, Juan,Liu, Qianrong,et al. Fluorescence turn-on assay for detection of serum D-penicillamine based on papain@AuNCs-Cu2+ complex[J]. ANALYTICA CHIMICA ACTA,2018,1026:133-139. |
| APA | Chen, Yifan,Qiao, Juan,Liu, Qianrong,Zhang, Mingming,&Qi, Li.(2018).Fluorescence turn-on assay for detection of serum D-penicillamine based on papain@AuNCs-Cu2+ complex.ANALYTICA CHIMICA ACTA,1026,133-139. |
| MLA | Chen, Yifan,et al."Fluorescence turn-on assay for detection of serum D-penicillamine based on papain@AuNCs-Cu2+ complex".ANALYTICA CHIMICA ACTA 1026(2018):133-139. |
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来源：化学研究所
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