Hydroxypropylmethyl cellulose (HPMC) crosslinked chitosan (CH) based scaffolds containing bioactive glass (BG) and zinc oxide (ZnO) for alveolar bone repair
文献类型：期刊论文
| 作者 | Zeeshan, Rabia1; Mutahir, Zeeshan2; Iqbal, Haffsah1; Ali, Moazzam2; Iqbal, Farasat1; Ijaz, Kashif1; Sharif, Faiza1; Shah, Asma Tufail1; Chaudhry, Aqif Anwar1; Yar, Muhammad1 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2018-08-01 |
| 卷号 | 193页码:9-18 |
| 关键词 | Chitosan (Ch) Hydroxypropylmethyl Cellulose (Hpmc) Bioactive Glass (Bg) Zinc Oxide (Zno) Antibacterial Pre-osteoblast Cells Alveolar Bone Repair Tissue Engineering (Te) |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.03.046 |
| 英文摘要 | The success of a dental implant relies on the presence of an optimal alveolar ridge. The aim of this study was to fabricate HPMC crosslinked chitosan based scaffolds for alveolar bone repair. Our results indicated that HPMC crosslinked CH/BG foams presented better morphological structure (132-90.5 mu m) and mechanical responses (0.451 MPa with 100 mg BG) as confirmed by SEM analysis and fatigue testing respectively. Cytotoxicity analysis at day 2, 4 and 8 demonstrated that all composites were non-toxic and supported cellular viability. Calcein AM/propidium iodide staining, Hoechst nuclear staining and cell adhesion assay reiterated that scaffolds supported pre-osteoblast cell growth, adhesion and proliferation. Differentiation potential of pre-osteoblast cells was enhanced as confirmed by alkaline phosphate assay. Furthermore, loss of S. aureus viability as low as 35% was attributed to synergistic effects of components. Overall, our results suggest that HPMC crosslinked scaffolds are potential candidates for alveolar bone repair. |
| 语种 | 英语 |
| WOS记录号 | WOS:000432775700002 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42759]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Khan, Ather Farooq |
| 作者单位 | 1.COMSATS Inst Informat Technol, Interdisciplinary Res Ctr Biomed Mat, Def Rd,Off Raiwind Rd, Lahore 54000, Pakistan 2.Univ Punjab, Inst Biochem & Biotechnol, Lahore 54590, Pakistan 3.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Jilin, Peoples R China 4.Univ Sheffield, Kroto Res Inst, North Campus,Broad Lane, Sheffield S3 7HQ, S Yorkshire, England |
| 推荐引用方式 GB/T 7714 | Zeeshan, Rabia,Mutahir, Zeeshan,Iqbal, Haffsah,et al. Hydroxypropylmethyl cellulose (HPMC) crosslinked chitosan (CH) based scaffolds containing bioactive glass (BG) and zinc oxide (ZnO) for alveolar bone repair[J]. CARBOHYDRATE POLYMERS,2018,193:9-18. |
| APA | Zeeshan, Rabia.,Mutahir, Zeeshan.,Iqbal, Haffsah.,Ali, Moazzam.,Iqbal, Farasat.,...&Ihtesham-ur-Rehman.(2018).Hydroxypropylmethyl cellulose (HPMC) crosslinked chitosan (CH) based scaffolds containing bioactive glass (BG) and zinc oxide (ZnO) for alveolar bone repair.CARBOHYDRATE POLYMERS,193,9-18. |
| MLA | Zeeshan, Rabia,et al."Hydroxypropylmethyl cellulose (HPMC) crosslinked chitosan (CH) based scaffolds containing bioactive glass (BG) and zinc oxide (ZnO) for alveolar bone repair".CARBOHYDRATE POLYMERS 193(2018):9-18. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。