Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe
文献类型：期刊论文
| 作者 | Wang, Weizhi1,2; Ma, Zhuoran2; Zhu, Shoujun2; Wan, Hao2; Yue, Jingying2; Ma, Huilong3; Ma, Rui3; Yang, Qinglai3; Wang, Zihua1,4; Li, Qian4 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2018-05-29 |
| 卷号 | 30期号:22 |
| 关键词 | Molecular Imaging Peptide Probe Renal-excretion Second Near-infrared Window Tumor Targeting |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.201800106 |
| 英文摘要 | In vivo molecular imaging of tumors targeting a specific cancer cell marker is a promising strategy for cancer diagnosis and imaging guided surgery and therapy. While targeted imaging often relies on antibody-modified probes, peptides can afford targeting probes with small sizes, high penetrating ability, and rapid excretion. Recently, in vivo fluorescence imaging in the second near-infrared window (NIR-II, 1000-1700 nm) shows promise in reaching sub-centimeter depth with microscale resolution. Here, a novel peptide (named CP) conjugated NIR-II fluorescent probe is reported for molecular tumor imaging targeting a tumor stem cell biomarker CD133. The click chemistry derived peptide-dye (CP-IRT dye) probe afforded efficient in vivo tumor targeting in mice with a high tumor-to-normal tissue signal ratio (T/NT > 8). Importantly, the CP-IRT probes are rapidly renal excreted (approximate to 87% excretion within 6 h), in stark contrast to accumulation in the liver for typical antibody-dye probes. Further, with NIR-II emitting CP-IRT probes, urethra of mice can be imaged fluorescently for the first time noninvasively through intact tissue. The NIR-II fluorescent, CD133 targeting imaging probes are potentially useful for human use in the clinic for cancer diagnosis and therapy. |
| 语种 | 英语 |
| WOS记录号 | WOS:000434034100025 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42825]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Hu, Zhiyuan; Liang, Yongye; Dai, Hongjie |
| 作者单位 | 1.Natl Ctr Nanosci & Technol China, CAS Ctr Excellence Nanosci, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Key Lab Standardizat & Measurement Nanotechno, Beijing 100190, Peoples R China 2.Stanford Univ, Dept Chem, Stanford, CA 94305 USA 3.South Univ Sci & Technol China, Dept Mat Sci & Engn, Shenzhen 518055, Peoples R China 4.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 5.Univ Chinese Acad Sci, Sinodanish Coll, Beijing 100049, Peoples R China 6.Fujian Med Univ, Sch Basic Med Sci, Ctr Neurosci Res, Fuzhou 350108, Fujian, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Weizhi,Ma, Zhuoran,Zhu, Shoujun,et al. Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe[J]. ADVANCED MATERIALS,2018,30(22). |
| APA | Wang, Weizhi.,Ma, Zhuoran.,Zhu, Shoujun.,Wan, Hao.,Yue, Jingying.,...&Dai, Hongjie.(2018).Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe.ADVANCED MATERIALS,30(22). |
| MLA | Wang, Weizhi,et al."Molecular Cancer Imaging in the Second Near-Infrared Window Using a Renal-Excreted NIR-II Fluorophore-Peptide Probe".ADVANCED MATERIALS 30.22(2018). |
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来源：化学研究所
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