Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer
文献类型：期刊论文
| 作者 | Guo, Xueling1,2; Zhuang, Qianfen1; Ji, Tianjiao3; Zhang, Yinlong3; Li, Changjian1,2; Wang, Yueqi1,2; Li, Hong1,2; Jia, Hongying1; Liu, Yang1; Du, Libo1 |
| 刊名 | CARBOHYDRATE POLYMERS
 |
| 出版日期 | 2018-09-01 |
| 卷号 | 195页码:311-320 |
| 关键词 | Anticancer Drug Delivery Nanoparticle Cell Imaging Aptamer |
| ISSN号 | 0144-8617 |
| DOI | 10.1016/j.carbpol.2018.04.087 |
| 英文摘要 | Chemotherapy-based treatment for cancer has made great progress in the past decades. However, there is still a big challenge for the treatment of lung cancer. Herein, a multifunctional nanocarrier was developed through electrostatic interaction between the fluorescent gold nanocluster-conjugated chitosan and the nucleolin targeting AS1411 aptamer. Then methotrexate was loaded into the multifunctional nanocarrier through hydrophobic interaction to obtain the nanodrug carrier systems. The prepared nanodrug carrier systems have an average nanoparticle size of 200 nm with 13.8% drug loading efficiency. The drug release is pH-dependent. The in vitro results demonstrated that the nanodrug carrier systems were selectively taken up by cancer cells in a time-dependent manner and exhibited significantly enhanced anticancer activity in a model of lung cancer A549 cells. The in vivo results showed that intravenous administration of nanodrug carrier systems into BALB/c mice led to accumulation of methotrexate at the tumor site and significantly inhibited the tumor growth but without overt toxicity. The present study suggests that the prepared multifunctional nanocarrier can be used as an effective drug delivery system for anticancer drugs and exhibits great potential in clinical applications. |
| 语种 | 英语 |
| WOS记录号 | WOS:000433204900036 |
| 出版者 | ELSEVIER SCI LTD |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42863]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Liu, Yang; Du, Libo |
| 作者单位 | 1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China 3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Guo, Xueling,Zhuang, Qianfen,Ji, Tianjiao,et al. Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer[J]. CARBOHYDRATE POLYMERS,2018,195:311-320. |
| APA | Guo, Xueling.,Zhuang, Qianfen.,Ji, Tianjiao.,Zhang, Yinlong.,Li, Changjian.,...&Du, Libo.(2018).Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer.CARBOHYDRATE POLYMERS,195,311-320. |
| MLA | Guo, Xueling,et al."Multi-functionalized chitosan nanoparticles for enhanced chemotherapy in lung cancer".CARBOHYDRATE POLYMERS 195(2018):311-320. |
入库方式： OAI收割
来源：化学研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。