Conjugated Polymer with Aggregation-Directed Intramolecular Forster Resonance Energy Transfer Enabling Efficient Discrimination and Killing of Microbial Pathogens
文献类型：期刊论文
| 作者 | Zhu, Shuxian1; Wang, Xiaoyu1; Yang, Yu1; Bai, Haotian2; Cui, Qianling1; Sun, Han2; Li, Lidong1,3; Wang, Shu2 |
| 刊名 | CHEMISTRY OF MATERIALS
 |
| 出版日期 | 2018-05-22 |
| 卷号 | 30期号:10页码:3244-3253 |
| ISSN号 | 0897-4756 |
| DOI | 10.1021/acs.chemmater.8b00164 |
| 英文摘要 | Rapid and effective differentiation and killing of microbial pathogens are major challenges in the diagnosis and treatment of infectious diseases. Here, we report a novel system based on the conjugated polymer poly[(9,9-bis{6'-[N-(triethylene glycol methyl ether)-di(1H-imidazolium)-methane]hexyl}-2,7-fluorene)-co-4,7-di-2-thieny1-2,1,3-benzo-thiadiazole] tetrabromide (PFDBT-BIMEG), which enables efficient microbial pathogen discrimination and killing. The functional side chains of PFDBT-BIMEG enabled both electrostatic and salt bridge interactions with microorganisms. Microorganism binding events caused a change in the aggregation structure of PFDBT-BIMEG, which could be recognized by a change of its fluorescence signal by intramolecular Forster resonance energy transfer (FRET). This sensing strategy allowed rapid and sensitive distinction of microbial pathogens within 15 min. We performed linear discrimination analysis that featured this advance to confirm that the polymer PFDBT-BIMEG could accurately classify microbial pathogens. Owing to the different adhesion mechanism of PFDBT-BIMEG to the surface of the microorganisms, we applied different sterilization strategies for each kind of microbial pathogen. The microbial pathogens could be efficiently killed by reactive oxygen species produced from PFDBT-BIMEG under irradiation, avoiding the use of any other antibacterial agents. This methodology, which combines pathogen discrimination and killing, represents a promising alternative to current diagnostic platforms. |
| 语种 | 英语 |
| WOS记录号 | WOS:000433403800010 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://ir.iccas.ac.cn/handle/121111/42957]  |
| 专题 | 中国科学院化学研究所 |
| 通讯作者 | Li, Lidong; Wang, Shu |
| 作者单位 | 1.Univ Sci & Technol Beijing, Sch Mat Sci & Engn, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Chem, Key Lab Organ Solids, Beijing 100190, Peoples R China 3.Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116024, Liaoning, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhu, Shuxian,Wang, Xiaoyu,Yang, Yu,et al. Conjugated Polymer with Aggregation-Directed Intramolecular Forster Resonance Energy Transfer Enabling Efficient Discrimination and Killing of Microbial Pathogens[J]. CHEMISTRY OF MATERIALS,2018,30(10):3244-3253. |
| APA | Zhu, Shuxian.,Wang, Xiaoyu.,Yang, Yu.,Bai, Haotian.,Cui, Qianling.,...&Wang, Shu.(2018).Conjugated Polymer with Aggregation-Directed Intramolecular Forster Resonance Energy Transfer Enabling Efficient Discrimination and Killing of Microbial Pathogens.CHEMISTRY OF MATERIALS,30(10),3244-3253. |
| MLA | Zhu, Shuxian,et al."Conjugated Polymer with Aggregation-Directed Intramolecular Forster Resonance Energy Transfer Enabling Efficient Discrimination and Killing of Microbial Pathogens".CHEMISTRY OF MATERIALS 30.10(2018):3244-3253. |
入库方式： OAI收割
来源：化学研究所
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